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@ARTICLE{Sha:278348,
      author       = {S. Sha$^*$ and L.-J. Chen$^*$ and H. Brenner$^*$ and B.
                      Schöttker$^*$},
      title        = {{A}ssociations of 25-hydroxyvitamin {D} status and vitamin
                      {D} supplementation use with mortality due to 18 frequent
                      cancer types in the {UK} {B}iobank cohort.},
      journal      = {European journal of cancer},
      volume       = {191},
      issn         = {0014-2964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01605},
      pages        = {113241},
      year         = {2023},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Although the associations of serum 25-hydroxyvitamin D
                      (25(OH)D) levels and vitamin D supplementation with total
                      cancer mortality are well-known, evidence regarding the
                      association of 25(OH)D and cancer site-specific mortality is
                      predominantly limited to common cancer types, and most
                      studies on vitamin D supplementation use have limitations on
                      sample size and the adjustment of important confounding
                      factors.We used cause-specific Cox regression models
                      adjusted for 48 covariates to assess the associations of
                      vitamin D deficiency, insufficiency, and vitamin D
                      supplementation use with mortality from any cancer and 18
                      specific cancers in 411,436 United Kingdom Biobank
                      participants, aged 40-69 years.The majority of the study
                      population had either vitamin D deficiency $(21.1\%)$ or
                      insufficiency $(34.4\%).$ Furthermore, $4.1\%$ and $20.3\%$
                      of the participants regularly took vitamin D or multivitamin
                      supplements, respectively. During a median follow-up of 12.7
                      years, vitamin D deficiency was associated with
                      significantly increased mortality from total cancer and four
                      specific cancers: stomach (hazard ratio, $95\%$ confidence
                      interval: 1.42, 1.05-1.92), colorectal (1.27, 1.07-1.50),
                      lung (1.24, 1.10-1.40), and prostate (1.36, 1.06-1.75).
                      Vitamin D insufficiency was associated with increased
                      colorectal (1.14, 1.00-1.30) and lung cancer mortality
                      (1.19, 1.08-1.32). Compared to non-users, vitamin D use was
                      associated with lower lung cancer (0.75, 0.60-0.95) and
                      total cancer mortality. Multivitamin use was associated with
                      lower mortality from melanoma (0.64, 0.43-0.97).Vitamin D
                      deficiency and insufficiency were associated with increased
                      mortality from multiple common cancers. The potential to
                      reduce cancer mortality by vitamin D supplementation in
                      populations with low 25(OH)D levels should be further
                      explored.},
      keywords     = {Cancer site-specific mortality (Other) / Real-world
                      evidence (Other) / Serum 25-hydroxyvitamin D levels (Other)
                      / Vitamin D supplement use (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37549530},
      doi          = {10.1016/j.ejca.2023.113241},
      url          = {https://inrepo02.dkfz.de/record/278348},
}