TY  - JOUR
AU  - Constantinescu, Andrei-Emil
AU  - Bull, Caroline J
AU  - Jones, Nicholas
AU  - Mitchell, Ruth
AU  - Burrows, Kimberley
AU  - Dimou, Niki
AU  - Bézieau, Stéphane
AU  - Brenner, Hermann
AU  - Buchanan, Daniel D
AU  - D'Amato, Mauro
AU  - Jenkins, Mark A
AU  - Moreno, Victor
AU  - Pai, Rish K
AU  - Um, Caroline Y
AU  - White, Emily
AU  - Murphy, Neil
AU  - Gunter, Marc
AU  - Timpson, Nicholas J
AU  - Huyghe, Jeroen R
AU  - Vincent, Emma E
TI  - Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomisation study.
JO  - International journal of cancer
VL  - 154
IS  - 1
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2023-01656
SP  - 94-103
PY  - 2024
N1  - 2024 Jan 1;154(1):94-103
AB  - Observational studies have suggested a protective role for eosinophils in colorectal cancer (CRC) development and implicated neutrophils, but the causal relationships remain unclear. Here, we aimed to estimate the causal effect of circulating white blood cell (WBC) counts (N =  550 000) for basophils, eosinophils, monocytes, lymphocytes and neutrophils on CRC risk (N = 52 775 cases and 45 940 controls) using Mendelian randomisation (MR). For comparison, we also examined this relationship using individual-level data from UK Biobank (4043 incident CRC cases and 332 773 controls) in a longitudinal cohort analysis. The inverse-variance weighted (IVW) MR analysis suggested a protective effect of increased basophil count and eosinophil count on CRC risk [OR per 1-SD increase: 0.88, 95
KW  - Mendelian randomisation (Other)
KW  - UK biobank (Other)
KW  - White blood cell count (Other)
KW  - colorectal cancer (Other)
KW  - eosinophils (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37578112
DO  - DOI:10.1002/ijc.34691
UR  - https://inrepo02.dkfz.de/record/278422
ER  -