TY  - JOUR
AU  - Heuer, Sophie
AU  - Winkler, Frank
TI  - Glioblastoma revisited: from neuronal-like invasion to pacemaking.
JO  - Trends in cancer
VL  - 9
IS  - 11
SN  - 2405-8033
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2023-01668
SP  - 887-896
PY  - 2023
N1  - #EA:B320#LA:B320# / 2023 Nov;9(11):887-896
AB  - In recent years, two developments have helped us to better understand the fundamental biology of glioblastoma: the description of a striking intratumoral heterogeneity including gene expression-based cell states, and the discovery that neuro-cancer interactions and cancer-intrinsic neurodevelopmental mechanisms are fundamental features of glioblastoma. In this opinion article, we aim to integrate both developments. We explain how two key disease features are characterized by different neural mechanisms related to distinct but plastic cancer cell states: first, the single cell-dominated invasive parts and second, the more solid parts which are dominated by communicating cell networks constantly activated by pacemaker-like glioblastoma cells. The resulting integrative roadmap of molecular and functional heterogeneity contributes to the Cancer Neuroscience of glioblastoma and suggests novel therapeutic strategies.
KW  - cancer neuroscience (Other)
KW  - cellular heterogeneity (Other)
KW  - glioblastoma (Other)
KW  - invasion (Other)
KW  - neuron-glioma synapse (Other)
KW  - tumor cell network (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37586918
DO  - DOI:10.1016/j.trecan.2023.07.009
UR  - https://inrepo02.dkfz.de/record/278587
ER  -