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@ARTICLE{Heuer:278587,
      author       = {S. Heuer$^*$ and F. Winkler$^*$},
      title        = {{G}lioblastoma revisited: from neuronal-like invasion to
                      pacemaking.},
      journal      = {Trends in cancer},
      volume       = {9},
      number       = {11},
      issn         = {2405-8033},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01668},
      pages        = {887-896},
      year         = {2023},
      note         = {#EA:B320#LA:B320# / 2023 Nov;9(11):887-896},
      abstract     = {In recent years, two developments have helped us to better
                      understand the fundamental biology of glioblastoma: the
                      description of a striking intratumoral heterogeneity
                      including gene expression-based cell states, and the
                      discovery that neuro-cancer interactions and
                      cancer-intrinsic neurodevelopmental mechanisms are
                      fundamental features of glioblastoma. In this opinion
                      article, we aim to integrate both developments. We explain
                      how two key disease features are characterized by different
                      neural mechanisms related to distinct but plastic cancer
                      cell states: first, the single cell-dominated invasive parts
                      and second, the more solid parts which are dominated by
                      communicating cell networks constantly activated by
                      pacemaker-like glioblastoma cells. The resulting integrative
                      roadmap of molecular and functional heterogeneity
                      contributes to the Cancer Neuroscience of glioblastoma and
                      suggests novel therapeutic strategies.},
      subtyp        = {Review Article},
      keywords     = {cancer neuroscience (Other) / cellular heterogeneity
                      (Other) / glioblastoma (Other) / invasion (Other) /
                      neuron-glioma synapse (Other) / tumor cell network (Other)},
      cin          = {B320 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B320-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37586918},
      doi          = {10.1016/j.trecan.2023.07.009},
      url          = {https://inrepo02.dkfz.de/record/278587},
}