%0 Journal Article
%A Hope, Thomas A
%A Benz, Matthias
%A Jiang, Fei
%A Thompson, Daniel
%A Barbato, Francesco
%A Juarez, Roxana
%A Hernandez Pampaloni, Miguel
%A Allen-Auerbach, Martin
%A Gupta, Pawan
%A Fendler, Wolfgang P
%A Calais, Jeremie
%T Do Bone Scans Overstage Disease Compared with PSMA PET at Initial Staging? An International Multicenter Retrospective Study with Masked Independent Readers.
%J Journal of nuclear medicine
%V 64
%N 11
%@ 0097-9058
%C New York, NY
%I Soc.
%M DKFZ-2023-01673
%P 1744-1747
%D 2023
%Z 2023 Nov;64(11):1744-1747
%X Prostate-specific membrane antigen (PSMA) PET has a higher accuracy than CT and bone scans to stage patients with prostate cancer. We do not understand how to apply clinical trial data based on conventional imaging to patients staged using PSMA PET. Therefore, we aimed to evaluate the ability of bone scans to detect osseous metastases using PSMA PET as a reference standard. Methods: In this multicenter retrospective diagnostic study, 167 patients with prostate cancer, who were imaged with bone scans and PSMA PET performed within 100 d, were included for analysis. Each study was interpreted by 3 masked readers, and the results of the PSMA PET were used as the reference standard. Endpoints were positive predictive value (PPV), negative predictive value (NPV), and specificity for bone scans. Additionally, interreader reproducibility, positivity rate, uptake on PSMA PET, and the number of lesions were evaluated. Results: In total, 167 patients were included, with 77 at initial staging, 60 in the biochemical recurrence and castration-sensitive prostate cancer setting, and 30 in the castration-resistant prostate cancer setting. In all patients, the PPV, NPV, and specificity for bone scans were 0.73 (95
%K PSMA PET (Other)
%K bone scans (Other)
%K initial staging (Other)
%K oncology (Other)
%K prostate cancer (Other)
%K radiopharmaceuticals (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37591547
%R 10.2967/jnumed.123.265916
%U https://inrepo02.dkfz.de/record/278614