TY  - JOUR
AU  - Piazena, Helmut
AU  - Vaupel, Peter
AU  - Thomsen, Andreas R
TI  - Clinical wIRA-hyperthermia: heating properties and effectiveness in lower trunk regions and its accordance with ESHO quality criteria for superficial hyperthermia.
JO  - International journal of hyperthermia and thermal therapies
VL  - 40
IS  - 1
SN  - 0265-6736
CY  - London
PB  - Informa UK Limited
M1  - DKFZ-2023-01675
SP  - 2244208
PY  - 2023
AB  - The heating characteristics of water-filtered infrared-A (wIRA) radiation were investigated in vivo in two body regions of healthy humans according to the quality standards of the European Society for Hyperthermic Oncology (ESHO) using an irradiance (infrared-A) of 146 W m-2 as recommended for clinical superficial hyperthermia (HT).wIRA was applied to the abdominal wall and lumbar region for 60 min. Skin surface temperature was limited to ≤43 °C. Tissue temperatures were measured invasively at 1-min intervals before, during and after wIRA exposure using five fiber-optical probes at depths of 1-20 mm.Significant differences between body regions occurred during the heating-up phase at depths of 5-15 mm. Thermal steady states were reached at depths ≤5 mm after exposures of 5-6 min, and ≤20 mm after 20 min. On average, the minimum requirements of ESHO were exceeded in both regions by the following factors: ≈3 for the heating rate, ≈2 for the specific absorption rate and ≈1.4 for the temperature rise. Tissue depths with T90 ≥ 40 °C and T50 > 41 °C were ≤10 mm, and ≤20 mm for Tmax ≤ 43 °C. The temperature decay time after termination of irradiation was 1-5 min. Corresponding temperatures were ≤42.2 °C for CEM43 and ≤41.8 °C for CEM43T90, i.e., they are inadequate for direct thermal cell killing.Thermography-controlled wIRA-HT complies with the ESHO criteria for superficial HT as a radiosensitizer and avoids the risk of thermal skin toxicity.
KW  - ESHO guidelines (Other)
KW  - Water-filtered infrared-A (wIRA) irradiation (Other)
KW  - mild hyperthermia (Other)
KW  - skin thermography (Other)
KW  - superficial hyperthermia (Other)
KW  - tissue thermometry (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37592457
DO  - DOI:10.1080/02656736.2023.2244208
UR  - https://inrepo02.dkfz.de/record/278616
ER  -