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@ARTICLE{Piazena:278616,
      author       = {H. Piazena and P. Vaupel$^*$ and A. R. Thomsen$^*$},
      title        = {{C}linical w{IRA}-hyperthermia: heating properties and
                      effectiveness in lower trunk regions and its accordance with
                      {ESHO} quality criteria for superficial hyperthermia.},
      journal      = {International journal of hyperthermia and thermal
                      therapies},
      volume       = {40},
      number       = {1},
      issn         = {0265-6736},
      address      = {London},
      publisher    = {Informa UK Limited},
      reportid     = {DKFZ-2023-01675},
      pages        = {2244208},
      year         = {2023},
      abstract     = {The heating characteristics of water-filtered infrared-A
                      (wIRA) radiation were investigated in vivo in two body
                      regions of healthy humans according to the quality standards
                      of the European Society for Hyperthermic Oncology (ESHO)
                      using an irradiance (infrared-A) of 146 W m-2 as recommended
                      for clinical superficial hyperthermia (HT).wIRA was applied
                      to the abdominal wall and lumbar region for 60 min. Skin
                      surface temperature was limited to ≤43 °C. Tissue
                      temperatures were measured invasively at 1-min intervals
                      before, during and after wIRA exposure using five
                      fiber-optical probes at depths of 1-20 mm.Significant
                      differences between body regions occurred during the
                      heating-up phase at depths of 5-15 mm. Thermal steady states
                      were reached at depths ≤5 mm after exposures of 5-6 min,
                      and ≤20 mm after 20 min. On average, the minimum
                      requirements of ESHO were exceeded in both regions by the
                      following factors: ≈3 for the heating rate, ≈2 for the
                      specific absorption rate and ≈1.4 for the temperature
                      rise. Tissue depths with T90 ≥ 40 °C and T50 > 41 °C
                      were ≤10 mm, and ≤20 mm for Tmax ≤ 43 °C. The
                      temperature decay time after termination of irradiation was
                      1-5 min. Corresponding temperatures were ≤42.2 °C for
                      CEM43 and ≤41.8 °C for CEM43T90, i.e., they are
                      inadequate for direct thermal cell
                      killing.Thermography-controlled wIRA-HT complies with the
                      ESHO criteria for superficial HT as a radiosensitizer and
                      avoids the risk of thermal skin toxicity.},
      keywords     = {ESHO guidelines (Other) / Water-filtered infrared-A (wIRA)
                      irradiation (Other) / mild hyperthermia (Other) / skin
                      thermography (Other) / superficial hyperthermia (Other) /
                      tissue thermometry (Other)},
      cin          = {FR01},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37592457},
      doi          = {10.1080/02656736.2023.2244208},
      url          = {https://inrepo02.dkfz.de/record/278616},
}