TY  - JOUR
AU  - Dettmer-Monaco, Viviane
AU  - Weißert, Kristoffer
AU  - Ammann, Sandra
AU  - Monaco, Gianni
AU  - Lei, Lei
AU  - Gräßel, Linda
AU  - Rhiel, Manuel
AU  - Rositzka, Julia
AU  - Kaufmann, Masako M
AU  - Geiger, Kerstin
AU  - Andrieux, Geoffroy
AU  - Lao, Jessica
AU  - Thoulass, Gudrun
AU  - Schell, Christoph
AU  - Börries, Melanie
AU  - Illert, Anna Lena
AU  - Cornu, Tatjana I
AU  - Ehl, Stephan
AU  - Aichele, Peter
AU  - Cathomen, Toni
TI  - Gene editing of hematopoietic stem cells restores T cell response in familial hemophagocytic lymphohistiocytosis.
JO  - The journal of allergy and clinical immunology
VL  - 153
IS  - 1
SN  - 0091-6749
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-01687
SP  - 243-255.e14
PY  - 2024
N1  - 2024 Jan;153(1):243-255.e14
AB  - Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory disorder characterized by a life-threatening cytokine storm and immunopathology. Familial HLH type 3 (FHL3) accounts for ∼30
KW  - CAST-Seq (Other)
KW  - CRISPR-Cas (Other)
KW  - T cell repertoire (Other)
KW  - autologous stem cell transplantation (Other)
KW  - gene therapy (Other)
KW  - genome editing (Other)
KW  - genotoxicity (Other)
KW  - hemophagocytic lymphohistiocytosis (Other)
KW  - hyperinflammation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37595758
DO  - DOI:10.1016/j.jaci.2023.08.003
UR  - https://inrepo02.dkfz.de/record/278643
ER  -