TY  - JOUR
AU  - Heesen, Philip
AU  - Ranft, Andreas
AU  - Bhadri, Vivek
AU  - Brichard, Benedicte
AU  - Collaud, Stephane
AU  - Cyprova, Sona
AU  - Eich, Hans
AU  - Ek, Torben
AU  - Gelderblom, Hans
AU  - Hardes, Jendrik
AU  - Haveman, Lianne
AU  - Jabar, Susanne
AU  - Hartmann, Wolfgang
AU  - Andreou, Dimosthenis
AU  - Hauser, Peter
AU  - Kersting, Josephine
AU  - Juergens, Heribert
AU  - Kanerva, Jukka
AU  - Kühne, Thomas
AU  - Raciborska, Anna
AU  - Rascon, Jelena
AU  - Streitbürger, Arne
AU  - Timmermann, Beate
AU  - Uhlenbruch, Yasmin
AU  - Dirksen, Uta
TI  - Association between local treatment modalities and event-free survival, overall survival, and local recurrence in patients with localised Ewing Sarcoma. Report from the Ewing 2008 trial.
JO  - European journal of cancer
VL  - 192
SN  - 0014-2964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-01689
SP  - 113260
PY  - 2023
AB  - Local treatment is a crucial element in the standard of care for Ewing sarcoma (EWS). While systemic treatment is improved in randomised clinical trials, local treatment modalities are discussed controversially. We analysed the association between local therapy and event-free survival (EFS), overall survival (OS), and local recurrence (LR) in prospectively collected data of patients with localised EWS.We analysed data from the international Ewing 2008 study registered between 2009 and 2019 in 117 centres. After induction chemotherapy, patients received surgery, radiotherapy, or a combination thereof. We performed Cox regression, conducted propensity score-weighted sensitivity analysis, and performed subgroup analyses. Hazard ratios (HRs) and 95
KW  - Bone tumour (Other)
KW  - Ewing sarcoma (Other)
KW  - Local therapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37595489
DO  - DOI:10.1016/j.ejca.2023.113260
UR  - https://inrepo02.dkfz.de/record/278645
ER  -