TY  - JOUR
AU  - Pham, Thu Thi
AU  - Nimptsch, Katharina
AU  - Papadimitriou, Nikos
AU  - Aleksandrova, Krasimira
AU  - Jenab, Mazda
AU  - Gunter, Marc J
AU  - Le Marchand, Loic
AU  - Li, Li
AU  - Lynch, Brigid M
AU  - Castellví-Bel, Sergi
AU  - Phipps, Amanda I
AU  - Schmit, Stephanie L
AU  - Brenner, Hermann
AU  - Ogino, Shuji
AU  - Giovannucci, Edward
AU  - Pischon, Tobias
TI  - Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study.
JO  - Journal of cancer research and clinical oncology
VL  - 149
IS  - 16
SN  - 0301-1585
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2023-01690
SP  - 14889-14900
PY  - 2023
N1  - 2023 Nov;149(16):14889-14900
AB  - Resistin, a novel pro-inflammatory protein implicated in inflammatory processes, has been suggested to play a role in colorectal development. However, evidence from observational studies has been inconsistent. Mendelian randomization may be a complementary method to examine this association.We conducted a two-sample Mendelian randomization to estimate the association between genetically determined circulating resistin concentrations and risk of colorectal cancer (CRC). Protein quantitative trait loci (pQTLs) from the SCALLOP consortium were used as instrumental variables (IVs) for resistin. CRC genetic summary data was obtained from GECCO/CORECT/CCFR (the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry), and FinnGen (Finland Biobank). The inverse variance weighted method (IVW) was applied in the main analysis, and other robust methods were used as sensitivity analyses. Estimates for the association from the two data sources were then pooled using a meta-analysis approach.Thirteen pQTLs were identified as IVs explaining together 7.80
KW  - Colorectal cancer (Other)
KW  - Genetic (Other)
KW  - Instrumental (Other)
KW  - Mendelian randomization (Other)
KW  - Resistin (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37599317
DO  - DOI:10.1007/s00432-023-05193-0
UR  - https://inrepo02.dkfz.de/record/278646
ER  -