TY  - JOUR
AU  - Gelderblom, Hans
AU  - Jones, Robin L
AU  - Blay, Jean-Yves
AU  - George, Suzanne
AU  - von Mehren, Margaret
AU  - Zalcberg, John R
AU  - Kang, Yoon-Koo
AU  - Razak, Albiruni Abdul
AU  - Trent, Jonathan
AU  - Attia, Steven
AU  - Le Cesne, Axel
AU  - Siontis, Brittany L
AU  - Goldstein, David
AU  - Boye, Kjetil
AU  - Sanchez, Cesar
AU  - Steeghs, Neeltje
AU  - Rutkowski, Piotr
AU  - Druta, Mihaela
AU  - Serrano, César
AU  - Somaiah, Neeta
AU  - Chi, Ping
AU  - Harrow, Brooke
AU  - Becker, Claus
AU  - Reichmann, William
AU  - Sherman, Matthew L
AU  - Ruiz-Soto, Rodrigo
AU  - Heinrich, Michael C
AU  - Bauer, Sebastian
TI  - Patient-reported outcomes and tolerability in patients receiving ripretinib versus sunitinib after treatment with imatinib in INTRIGUE, a phase 3, open-label study.
JO  - European journal of cancer
VL  - 192
SN  - 0014-2964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-01691
SP  - 113245
PY  - 2023
AB  - In the INTRIGUE trial, ripretinib showed no significant difference versus sunitinib in progression-free survival for patients with advanced gastrointestinal stromal tumour (GIST) previously treated with imatinib. We compared the impact of these treatments on health-related quality of life (HRQoL).Patients were randomised 1:1 to once-daily ripretinib 150 mg or once-daily sunitinib 50 mg (4 weeks on/2 weeks off). Patient-reported outcomes were assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for Cancer-30 (EORTC QLQ-C30) questionnaire at day (D)1, and D29 of all cycles until treatment discontinuation. Change from baseline was calculated. Time without symptoms or toxicity (TWiST) was estimated as the mean number of days without progression, death, or grade ≥3 treatment-emergent adverse events per patient over 1 year of follow-up.Questionnaire completion at baseline was 88.1
KW  - Gastrointestinal stromal tumours (Other)
KW  - Patient reported outcome measures (Other)
KW  - Protein kinase inhibitors (Other)
KW  - Quality of life (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37598656
DO  - DOI:10.1016/j.ejca.2023.113245
UR  - https://inrepo02.dkfz.de/record/278647
ER  -