% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Cirzi:278728,
      author       = {C. Cirzi$^*$ and J. Dyckow and C. Legrand$^*$ and J. Schott
                      and W. Guo and D. Perez Hernandez and M. Hisaoka and R.
                      Parlato and C. Pitzer and F. van der Hoeven$^*$ and G.
                      Dittmar and M. Helm and G. Stoecklin and L. Schirmer and F.
                      Lyko$^*$ and F. Tuorto$^*$},
      title        = {{Q}ueuosine-t{RNA} promotes sex-dependent learning and
                      memory formation by maintaining codon-biased translation
                      elongation speed.},
      journal      = {The EMBO journal},
      volume       = {42},
      number       = {19},
      issn         = {0261-4189},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DKFZ-2023-01699},
      pages        = {e112507},
      year         = {2023},
      note         = {#EA:A130#LA:A130# / DKFZ-ZMBH Alliance / 2023 Oct
                      4;42(19):e112507},
      abstract     = {Queuosine (Q) is a modified nucleoside at the wobble
                      position of specific tRNAs. In mammals, queuosinylation is
                      facilitated by queuine uptake from the gut microbiota and is
                      introduced into tRNA by the QTRT1-QTRT2 enzyme complex. By
                      establishing a Qtrt1 knockout mouse model, we discovered
                      that the loss of Q-tRNA leads to learning and memory
                      deficits. Ribo-Seq analysis in the hippocampus of
                      Qtrt1-deficient mice revealed not only stalling of ribosomes
                      on Q-decoded codons, but also a global imbalance in
                      translation elongation speed between codons that engage in
                      weak and strong interactions with their cognate anticodons.
                      While Q-dependent molecular and behavioral phenotypes were
                      identified in both sexes, female mice were affected more
                      severely than males. Proteomics analysis confirmed
                      deregulation of synaptogenesis and neuronal morphology.
                      Together, our findings provide a link between tRNA
                      modification and brain functions and reveal an unexpected
                      role of protein synthesis in sex-dependent cognitive
                      performance.},
      keywords     = {learning and memory (Other) / protein translation (Other) /
                      queuosine (Other) / sex bias (Other) / tRNA modifications
                      (Other)},
      cin          = {A130 / W450},
      ddc          = {570},
      cid          = {I:(DE-He78)A130-20160331 / I:(DE-He78)W450-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37609797},
      doi          = {10.15252/embj.2022112507},
      url          = {https://inrepo02.dkfz.de/record/278728},
}