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@ARTICLE{Fares:282344,
      author       = {A. F. Fares and Y. Li and M. Jiang and M. C. Brown and A.
                      C. L. Lam and R. Aggarwal and S. Schmid and N. B. Leighl and
                      F. A. Shepherd and Z. Wang and N. Diao and A. S. Wenzlaff
                      and J. Xie and T. Kohno and N. E. Caporaso and C. Harris and
                      H. Ma and M. J. Barnett and L. F. Leal and G.
                      Fernandez-Tardon and M. Pérez-Ríos and M. P. A. Davies and
                      F. Taylor and B. Schöttker$^*$ and P. Brennan and D.
                      Zaridze and I. Holcatova and J. Lissowska and B.
                      Świątkowska and D. Mates and M. Savic and H. Brenner$^*$
                      and A. Andrew and A. Cox and J. K. Field and A. Ruano-Ravina
                      and S. S. Shete and A. Tardon and Y. Wang and L. Le Marchand
                      and R. M. Reis and M. B. Schabath and C. Chen and H. Shen
                      and B. M. Ryan and M. T. Landi and K. Shiraishi and J. Zhang
                      and A. G. Schwartz and M. S. Tsao and D. C. Christiani and
                      P. Yang and R. J. Hung and W. Xu and G. Liu},
      title        = {{A}ssociation between duration of smoking abstinence before
                      non-small-cell lung cancer diagnosis and survival: a
                      retrospective, pooled analysis of cohort studies.},
      journal      = {The lancet / Public health},
      volume       = {8},
      number       = {9},
      issn         = {2468-2667},
      address      = {London},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01728},
      pages        = {e691 - e700},
      year         = {2023},
      abstract     = {The association between duration of smoking abstinence
                      before non-small-cell lung cancer (NSCLC) diagnosis and
                      subsequent survival can influence public health messaging
                      delivered in lung-cancer screening. We aimed to assess
                      whether the duration of smoking abstinence before diagnosis
                      of NSCLC is associated with improved survival.In this
                      retrospective, pooled analysis of cohort studies, we used 26
                      cohorts participating in Clinical Outcomes Studies of the
                      International Lung Cancer Consortium (COS-ILCCO) at 23
                      hospitals. 16 $(62\%)$ were from North America, six $(23\%)$
                      were from Europe, three $(12\%)$ were from Asia, and one
                      $(4\%)$ was from South America. Patients enrolled were
                      diagnosed between June 1, 1983, and Dec 31, 2019. Eligible
                      patients had smoking data before NSCLC diagnosis,
                      epidemiological data at diagnosis (obtained largely from
                      patient questionnaires), and clinical information (retrieved
                      from medical records). Kaplan-Meier curves and multivariable
                      Cox models (ie, adjusted hazard ratios [aHRs]) were
                      generated with individual, harmonised patient data from the
                      consortium database. We estimated overall survival for all
                      causes, measured in years from diagnosis date until the date
                      of the last follow-up or death due to any cause and
                      NSCLC-specific survival.Of 42 087 patients with NSCLC in the
                      COS-ILCCO database, 21 893 $(52·0\%)$ of whom were male and
                      20 194 $(48·0\%)$ of whom were female, we excluded 4474
                      $(10·6\%)$ with missing data. Compared with current smokers
                      (15 036 $[40·0\%]$ of 37 613), patients with 1-3 years of
                      smoking abstinence before NSCLC diagnosis (2890 $[7·7\%])$
                      had an overall survival aHR of 0·92 $(95\%$ CI
                      0·87-0·97), patients with 3-5 years of smoking abstinence
                      (1114 $[3·0\%])$ had an overall survival aHR of 0·90
                      (0·83-0·97), and patients with more than 5 years of
                      smoking abstinence (10 841 $[28·8\%])$ had an overall
                      survival aHR of 0·90 (0·87-0·93). Improved NSCLC-specific
                      survival was observed in 4301 $(44\%)$ of 9727 patients who
                      had quit cigarette smoking and was significant at abstinence
                      durations of more than 5 years (aHR 0·87, $95\%$ CI
                      0·81-0·93). Results were consistent across age, sex,
                      histology, and disease-stage distributions.In this large,
                      pooled analysis of cohort studies across Asia, Europe, North
                      America, and South America, overall survival was improved in
                      patients with NSCLC whose duration of smoking abstinence
                      before diagnosis was as short as 1 year. These findings
                      suggest that quitting smoking can improve overall survival,
                      even if NSCLC is diagnosed at a later lung-cancer screening
                      visit. These findings also support the implementation of
                      public health smoking cessation strategies at any time.The
                      Alan B Brown Chair, The Posluns Family Fund, The Lusi Wong
                      Fund, and the Princess Margaret Cancer Foundation.},
      keywords     = {Humans / Female / Male / Retrospective Studies / Carcinoma,
                      Non-Small-Cell Lung: diagnosis / Lung Neoplasms: diagnosis /
                      Cohort Studies / Smoking: epidemiology},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37633678},
      doi          = {10.1016/S2468-2667(23)00131-7},
      url          = {https://inrepo02.dkfz.de/record/282344},
}