TY  - JOUR
AU  - Breun, Maria
AU  - Flock, Katharina
AU  - Feldheim, Jonas
AU  - Nattmann, Anja
AU  - Monoranu, Camelia M
AU  - Herrmann, Pia
AU  - Ernestus, Ralf-Ingo
AU  - Löhr, Mario
AU  - Hagemann, Carsten
AU  - Stein, Ulrike
TI  - Metastasis Associated in Colorectal Cancer 1 (MACC1) mRNA Expression Is Enhanced in Sporadic Vestibular Schwannoma and Correlates to Deafness.
JO  - Cancers
VL  - 15
IS  - 16
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2023-01737
SP  - 4089
PY  - 2023
AB  - Vestibular schwannoma (VS) are benign cranial nerve sheath tumors of the vestibulocochlear nerve. Their incidence is mostly sporadic, but they can also be associated with NF2-related schwannomatosis (NF2), a hereditary tumor syndrome. Metastasis associated in colon cancer 1 (MACC1) is known to contribute to angiogenesis, cell growth, invasiveness, cell motility and metastasis of solid malignant cancers. In addition, MACC1 may be associated with nonsyndromic hearing impairment. Therefore, we evaluated whether MACC1 may be involved in the pathogenesis of VS. Sporadic VS, recurrent sporadic VS, NF2-associated VS, recurrent NF2-associated VS and healthy vestibular nerves were analyzed for MACC1 mRNA and protein expression by quantitative polymerase chain reaction and immunohistochemistry. MACC1 expression levels were correlated with the patients' clinical course and symptoms. MACC1 mRNA expression was significantly higher in sporadic VS compared to NF2-associated VS (p < 0.001). The latter expressed similar MACC1 concentrations as healthy vestibular nerves. Recurrent tumors resembled the MACC1 expression of the primary tumors. MACC1 mRNA expression was significantly correlated with deafness in sporadic VS patients (p = 0.034). Therefore, MACC1 might be a new molecular marker involved in VS pathogenesis.
KW  - NF2-related schwannomatosis (NF2) (Other)
KW  - deafness (Other)
KW  - mRNA expression (Other)
KW  - metastasis associated in colorectal cancer 1 (MACC1) (Other)
KW  - pathogenesis (Other)
KW  - vestibular schwannoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37627117
C2  - pmc:PMC10452285
DO  - DOI:10.3390/cancers15164089
UR  - https://inrepo02.dkfz.de/record/282353
ER  -