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@ARTICLE{Breun:282353,
      author       = {M. Breun and K. Flock and J. Feldheim and A. Nattmann and
                      C. M. Monoranu and P. Herrmann and R.-I. Ernestus and M.
                      Löhr and C. Hagemann and U. Stein$^*$},
      title        = {{M}etastasis {A}ssociated in {C}olorectal {C}ancer 1
                      ({MACC}1) m{RNA} {E}xpression {I}s {E}nhanced in {S}poradic
                      {V}estibular {S}chwannoma and {C}orrelates to {D}eafness.},
      journal      = {Cancers},
      volume       = {15},
      number       = {16},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01737},
      pages        = {4089},
      year         = {2023},
      abstract     = {Vestibular schwannoma (VS) are benign cranial nerve sheath
                      tumors of the vestibulocochlear nerve. Their incidence is
                      mostly sporadic, but they can also be associated with
                      NF2-related schwannomatosis (NF2), a hereditary tumor
                      syndrome. Metastasis associated in colon cancer 1 (MACC1) is
                      known to contribute to angiogenesis, cell growth,
                      invasiveness, cell motility and metastasis of solid
                      malignant cancers. In addition, MACC1 may be associated with
                      nonsyndromic hearing impairment. Therefore, we evaluated
                      whether MACC1 may be involved in the pathogenesis of VS.
                      Sporadic VS, recurrent sporadic VS, NF2-associated VS,
                      recurrent NF2-associated VS and healthy vestibular nerves
                      were analyzed for MACC1 mRNA and protein expression by
                      quantitative polymerase chain reaction and
                      immunohistochemistry. MACC1 expression levels were
                      correlated with the patients' clinical course and symptoms.
                      MACC1 mRNA expression was significantly higher in sporadic
                      VS compared to NF2-associated VS (p < 0.001). The latter
                      expressed similar MACC1 concentrations as healthy vestibular
                      nerves. Recurrent tumors resembled the MACC1 expression of
                      the primary tumors. MACC1 mRNA expression was significantly
                      correlated with deafness in sporadic VS patients (p =
                      0.034). Therefore, MACC1 might be a new molecular marker
                      involved in VS pathogenesis.},
      keywords     = {NF2-related schwannomatosis (NF2) (Other) / deafness
                      (Other) / mRNA expression (Other) / metastasis associated in
                      colorectal cancer 1 (MACC1) (Other) / pathogenesis (Other) /
                      vestibular schwannoma (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37627117},
      pmc          = {pmc:PMC10452285},
      doi          = {10.3390/cancers15164089},
      url          = {https://inrepo02.dkfz.de/record/282353},
}