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000282354 1001_ $$00000-0002-4805-0774$$aAlmanza-Aguilera, Enrique$$b0
000282354 245__ $$aIntake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study.
000282354 260__ $$aBasel$$bMDPI$$c2023
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000282354 520__ $$aExisting epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of PCa, including clinically relevant subtypes. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort included 131,425 adult men from seven European countries. (Poly)phenol intake at baseline was assessed by combining validated center/country-specific dietary questionnaires and the Phenol-Explorer database. Multivariable-adjusted Cox proportional hazards models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CI). In total, 6939 incident PCa cases (including 3501 low-grade and 710 high-grade, 2446 localized and 1268 advanced, and 914 fatal Pca cases) were identified during a mean follow-up of 14 years. No associations were observed between the total intake of (poly)phenols and the risk of PCa, either overall (HRlog2 = 0.99, 95% CI 0.94-1.04) or according to PCa subtype. Null associations were also found between all classes (phenolic acids, flavonoids, lignans, and stilbenes) and subclasses of (poly)phenol intake and the risk of PCa, overall and according to PCa subtype. The results of the current large prospective cohort study do not support any association between (poly)phenol intake and PCa incidence.
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000282354 650_7 $$2Other$$aEPIC
000282354 650_7 $$2Other$$acohort
000282354 650_7 $$2Other$$adiet
000282354 650_7 $$2Other$$aintake
000282354 650_7 $$2Other$$apolyphenols
000282354 650_7 $$2Other$$aprostate cancer
000282354 7001_ $$aGuiñón-Fort, Daniel$$b1
000282354 7001_ $$aPerez-Cornago, Aurora$$b2
000282354 7001_ $$00000-0002-7650-4016$$aMartínez-Huélamo, Miriam$$b3
000282354 7001_ $$00000-0002-8494-4978$$aAndrés-Lacueva, Cristina$$b4
000282354 7001_ $$00000-0003-4385-2097$$aTjønneland, Anne$$b5
000282354 7001_ $$aEriksen, Anne Kirstine$$b6
000282354 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b7$$udkfz
000282354 7001_ $$0P:(DE-He78)0b48ce513fe49013263657450a12f870$$aBajracharya, Rashmita$$b8$$udkfz
000282354 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b9
000282354 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b10
000282354 7001_ $$00000-0002-8624-9186$$aOliverio, Andreina$$b11
000282354 7001_ $$00000-0003-2666-414X$$aTumino, Rosario$$b12
000282354 7001_ $$aManfredi, Luca$$b13
000282354 7001_ $$aLasheras, Cristina$$b14
000282354 7001_ $$aCrous-Bou, Marta$$b15
000282354 7001_ $$00000-0003-4817-0757$$aSánchez, Maria-José$$b16
000282354 7001_ $$aAmiano, Pilar$$b17
000282354 7001_ $$00000-0002-6700-0780$$aColorado-Yohar, Sandra M$$b18
000282354 7001_ $$00000-0001-9242-6364$$aGuevara, Marcela$$b19
000282354 7001_ $$00000-0002-0747-4562$$aSonestedt, Emily$$b20
000282354 7001_ $$aBjartell, Anders$$b21
000282354 7001_ $$aThysell, Elin$$b22
000282354 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b23
000282354 7001_ $$00000-0002-4533-1722$$aAune, Dagfinn$$b24
000282354 7001_ $$00000-0002-0442-3284$$aAglago, Elom K$$b25
000282354 7001_ $$aTravis, Ruth C$$b26
000282354 7001_ $$00000-0002-6236-6804$$aZamora-Ros, Raul$$b27
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