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@ARTICLE{AlmanzaAguilera:282354,
      author       = {E. Almanza-Aguilera and D. Guiñón-Fort and A.
                      Perez-Cornago and M. Martínez-Huélamo and C.
                      Andrés-Lacueva and A. Tjønneland and A. K. Eriksen and V.
                      Katzke$^*$ and R. Bajracharya$^*$ and M. B. Schulze and G.
                      Masala and A. Oliverio and R. Tumino and L. Manfredi and C.
                      Lasheras and M. Crous-Bou and M.-J. Sánchez and P. Amiano
                      and S. M. Colorado-Yohar and M. Guevara and E. Sonestedt and
                      A. Bjartell and E. Thysell and E. Weiderpass and D. Aune and
                      E. K. Aglago and R. C. Travis and R. Zamora-Ros},
      title        = {{I}ntake of the {T}otal, {C}lasses, and {S}ubclasses of
                      ({P}oly){P}henols and {R}isk of {P}rostate {C}ancer: {A}
                      {P}rospective {A}nalysis of the {EPIC} {S}tudy.},
      journal      = {Cancers},
      volume       = {15},
      number       = {16},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01738},
      pages        = {4067},
      year         = {2023},
      abstract     = {Existing epidemiological evidence regarding the potential
                      role of (poly)phenol intake in prostate cancer (PCa) risk is
                      scarce and, in the case of flavonoids, it has been suggested
                      that their intake may increase PCa risk. We investigated the
                      associations between the intake of the total and individual
                      classes and subclasses of (poly)phenols and the risk of PCa,
                      including clinically relevant subtypes. The European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      cohort included 131,425 adult men from seven European
                      countries. (Poly)phenol intake at baseline was assessed by
                      combining validated center/country-specific dietary
                      questionnaires and the Phenol-Explorer database.
                      Multivariable-adjusted Cox proportional hazards models were
                      used to estimate the hazard ratios (HR) and $95\%$
                      confidence intervals (CI). In total, 6939 incident PCa cases
                      (including 3501 low-grade and 710 high-grade, 2446 localized
                      and 1268 advanced, and 914 fatal Pca cases) were identified
                      during a mean follow-up of 14 years. No associations were
                      observed between the total intake of (poly)phenols and the
                      risk of PCa, either overall (HRlog2 = 0.99, $95\%$ CI
                      0.94-1.04) or according to PCa subtype. Null associations
                      were also found between all classes (phenolic acids,
                      flavonoids, lignans, and stilbenes) and subclasses of
                      (poly)phenol intake and the risk of PCa, overall and
                      according to PCa subtype. The results of the current large
                      prospective cohort study do not support any association
                      between (poly)phenol intake and PCa incidence.},
      keywords     = {EPIC (Other) / cohort (Other) / diet (Other) / intake
                      (Other) / polyphenols (Other) / prostate cancer (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37627095},
      pmc          = {pmc:PMC10452452},
      doi          = {10.3390/cancers15164067},
      url          = {https://inrepo02.dkfz.de/record/282354},
}