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@ARTICLE{Zhang:282364,
      author       = {K. S. Zhang$^*$ and P. Mayer$^*$ and P. A. Glemser$^*$ and
                      A. A. Tavakoli$^*$ and M. Keymling$^*$ and L. T. Rotkopf$^*$
                      and C. Meinzer$^*$ and M. Görtz$^*$ and H.-U. Kauczor and
                      T. Hielscher$^*$ and A. Stenzinger and D. Bonekamp$^*$ and
                      M. Hohenfellner and H.-P. Schlemmer$^*$},
      title        = {{A}re {T}2{WI} {PI}-{RADS} sub-scores of transition zone
                      prostate lesions biased by {DWI} information? {A}
                      multi-reader, single-center study.},
      journal      = {European journal of radiology},
      volume       = {167},
      issn         = {0720-048x},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2023-01746},
      pages        = {111026},
      year         = {2023},
      note         = {#EA:E010#LA:E010#},
      abstract     = {According to PI-RADS v2.1, T2-weighted imaging (T2WI) is
                      the dominant sequence for transition zone (TZ) lesions. This
                      study aimed to assess, whether diffusion-weighted imaging
                      (DWI) information influences the assignment of T2WI
                      scores.Out of 283 prostate MRI examinations with correlated
                      biopsy results, fourty-four patients were selected
                      retrospectively: first, 22 patients with a TZ lesion with
                      T2WI and DWI scores ≥ 4, to represent lesions with
                      unequivocal suspicion on T2WI and DWI. Second, 22 additional
                      patients with TZ lesions of similar T2WI appearance but with
                      corresponding DWI score ≤ 3 were added as control. Four
                      residents and one board-certified radiologist each performed
                      two assessments of the included patients: First, only T2WI
                      was available (T2-only read); second, both T2WI and DWI
                      sequences were available (biparametric read). Lesion scores
                      were assessed using Wilcoxon signed-rank test, inter-reader
                      agreement using weighted kappa and Kendall's W statistics,
                      and sensitivity/specificity using McNemar test.The T2WI
                      scores were significantly different between the T2-only and
                      biparametric read for 3 out of 4 residents (p ≤ 0.049) but
                      not for the radiologist. The overall PI-RADS scores derived
                      from the two reading sessions differed considerably for
                      35/220 cases (all readers pooled). Inter-reader agreement
                      was fair for the T2WI and overall PI-RADS scores (mean kappa
                      0.27-0.30) and moderate for the DWI scores (mean kappa
                      0.43).For inexperienced readers, assessment of T2WI is
                      variable and potentially biased by availability of DWI
                      information, which can lead to changes of overall PI-RADS
                      score and consequently clinical management. Assessment of
                      T2WI should be performed before reviewing DWI to ensure
                      non-biased interpretation of TZ lesions in the dominant
                      sequence.},
      keywords     = {Magnetic resonance imaging (Other) / PI-RADS (Other) /
                      PIRADS (Other) / Prostate cancer (Other) / TZ (Other) /
                      Transition zone (Other)},
      cin          = {E010 / E250 / C060 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E250-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37639843},
      doi          = {10.1016/j.ejrad.2023.111026},
      url          = {https://inrepo02.dkfz.de/record/282364},
}