%0 Journal Article
%A Bouras, Emmanouil
%A Kim, Andre E
%A Lin, Yi
%A Morrison, John
%A Du, Mengmeng
%A Albanes, Demetrius
%A Barry, Elizabeth L
%A Baurley, James W
%A Berndt, Sonja I
%A Bien, Stephanie A
%A Bishop, Timothy D
%A Brenner, Hermann
%A Budiarto, Arif
%A Burnett-Hartman, Andrea
%A Campbell, Peter T
%A Carreras-Torres, Robert
%A Casey, Graham
%A Cenggoro, Tjeng Wawan
%A Chan, Andrew T
%A Chang-Claude, Jenny
%A Conti, David V
%A Cotterchio, Michelle
%A Devall, Matthew
%A Diez-Obrero, Virginia
%A Dimou, Niki
%A Drew, David A
%A Figueiredo, Jane C
%A Giles, Graham G
%A Gruber, Stephen B
%A Gunter, Marc J
%A Harrison, Tabitha A
%A Hidaka, Akihisa
%A Hoffmeister, Michael
%A Huyghe, Jeroen R
%A Joshi, Amit D
%A Kawaguchi, Eric S
%A Keku, Temitope O
%A Kundaje, Anshul
%A Le Marchand, Loic
%A Lewinger, Juan Pablo
%A Li, Li
%A Lynch, Brigid M
%A Mahesworo, Bharuno
%A Männistö, Satu
%A Moreno, Victor
%A Murphy, Neil
%A Newcomb, Polly A
%A Obón-Santacana, Mireia
%A Ose, Jennifer
%A Palmer, Julie R
%A Papadimitriou, Nikos
%A Pardamean, Bens
%A Pellatt, Andrew J
%A Peoples, Anita R
%A Platz, Elizabeth A
%A Potter, John D
%A Qi, Lihong
%A Qu, Conghui
%A Rennert, Gad
%A Ruiz-Narvaez, Edward
%A Sakoda, Lori C
%A Schmit, Stephanie L
%A Shcherbina, Anna
%A Stern, Mariana C
%A Su, Yu-Ru
%A Tangen, Catherine M
%A Thomas, Duncan C
%A Tian, Yu
%A Um, Caroline Y
%A van Duijnhoven, Franzel Jb
%A Van Guelpen, Bethany
%A Visvanathan, Kala
%A Wang, Jun
%A White, Emily
%A Wolk, Alicja
%A Woods, Michael O
%A Ulrich, Cornelia M
%A Hsu, Li
%A Gauderman, W James
%A Peters, Ulrike
%A Tsilidis, Konstantinos K
%T Genome-wide interaction analysis of folate for colorectal cancer risk.
%J The American journal of clinical nutrition
%V 118
%N 5
%@ 0095-9871
%C Oxford
%I Oxford University Press
%M DKFZ-2023-01747
%P 881-891
%D 2023
%Z 2023 Nov;118(5):881-891
%X Epidemiological and experimental evidence suggests that higher folate intake is associated with a decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate's role in CRC.Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk.We applied traditional case-control logistic regression, joint 3-degree of freedom (3DF), and a two-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1
%K CRC (Other)
%K European (Other)
%K GWIS (Other)
%K SYN2 (Other)
%K TIMP4 (Other)
%K colorectal cancer (Other)
%K folate (Other)
%K folic acid (Other)
%K genome-wide (Other)
%K interaction (Other)
%K synapsin (Other)
%K tissue inhibitor of metalloproteinase 4 (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37640106
%R 10.1016/j.ajcnut.2023.08.010
%U https://inrepo02.dkfz.de/record/282365