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@ARTICLE{Pertz:282443,
      author       = {M. Pertz and S. Schlömer and C. Seidel and B. Hentschel
                      and M. Löffler and G. Schackert and D. Krex and T. Juratli
                      and J. C. Tonn and O. Schnell and H. Vatter and M. Simon and
                      M. Westphal and T. Martens and M. Sabel and M. Bendszus and
                      N. Dörner and A. Wick$^*$ and K. Fliessbach and C. Hoppe
                      and M. Klingner and J. Felsberg and G. Reifenberger and D.
                      Gramatzki and M. Weller and U. Schlegel},
      collaboration = {G. G. Network},
      title        = {{L}ong-term neurocognitive function and quality of life
                      after multimodal therapy in adult glioma patients: a
                      prospective long-term follow-up.},
      journal      = {Journal of neuro-oncology},
      volume       = {164},
      number       = {2},
      issn         = {0167-594x},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V},
      reportid     = {DKFZ-2023-01763},
      pages        = {353-366},
      year         = {2023},
      note         = {2023 Sep;164(2):353-366},
      abstract     = {Multimodal therapies have significantly improved prognosis
                      in glioma. However, in particular radiotherapy may induce
                      long-term neurotoxicity compromising patients'
                      neurocognition and quality of life. The present prospective
                      multicenter study aimed to evaluate associations of
                      multimodal treatment with neurocognition with a particular
                      focus on hippocampal irradiation.Seventy-one glioma patients
                      (WHO grade 1-4) were serially evaluated with neurocognitive
                      testing and quality of life questionnaires. Prior to
                      (baseline) and following further treatment (median 7.1 years
                      [range 4.6-11.0] after baseline) a standardized computerized
                      neurocognitive test battery (NeuroCog FX) was applied to
                      gauge psychomotor speed and inhibition, verbal short-term
                      memory, working memory, verbal and non-verbal memory as well
                      as verbal fluency. Mean ipsilateral hippocampal radiation
                      dose was determined in a subgroup of 27 patients who
                      received radiotherapy according to radiotherapy plans to
                      evaluate its association with neurocognition.Between
                      baseline and follow-up mean performance in none of the
                      cognitive domains significantly declined in any treatment
                      modality (radiotherapy, chemotherapy, combined
                      radio-chemotherapy, watchful-waiting), except for selective
                      attention in patients receiving chemotherapy alone. Apart
                      from one subtest (inhibition), mean ipsilateral hippocampal
                      radiation dose > 50 Gy (Dmean) as compared to < 10 Gy showed
                      no associations with long-term cognitive functioning.
                      However, patients with Dmean < 10 Gy showed stable or
                      improved performance in all cognitive domains, while
                      patients with > 50 Gy numerically deteriorated in 4/8
                      domains.Multimodal glioma therapy seems to affect
                      neurocognition less than generally assumed. Even patients
                      with unilateral hippocampal irradiation with > 50 Gy showed
                      no profound cognitive decline in this series.},
      keywords     = {Glioma (Other) / Multimodal tumor-directed treatment
                      (Other) / Neurocognition (Other) / Quality of life (Other) /
                      Radiotherapy (Other)},
      cin          = {B320 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B320-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37648934},
      doi          = {10.1007/s11060-023-04419-y},
      url          = {https://inrepo02.dkfz.de/record/282443},
}