%0 Journal Article
%A Schneider, Thomas
%A Zwicker, Felix
%A Huber, Peter Ernst
%A Debus, Jürgen
%A Hauswald, Henrik
%T In Vitro Carbon Ion Beam and Gemcitabine Chemoradiation in a Mucoepidermoid Carcinoma Cell Line.
%J In vivo
%V 37
%N 5
%@ 0258-851x
%C Kapandriti, Attiki
%I IIAR
%M DKFZ-2023-01776
%P 1951 - 1959
%D 2023
%Z #EA:E055#LA:E055#
%X To determine the interaction of gemcitabine in chemoradiotherapy with heavy carbon ions in vitro in a mucoepidermoid carcinoma (MEC) cell line.The human lymphatic MEC metastasis cell line NCI-H292 was used. The cells were treated with photons, carbon ions, and gemcitabine. Survival fractions (SF), apoptosis, and cell cycle progression were analyzed. A paired two-sided t-test was used. Significance was defined as p<0.05.Cell proliferation assays showed a significant reduction in SF for combined photon chemoradiation versus photons only. The linear-quadratic fits of combined therapy with carbon ion dose of 0 to 2.5 Gy led to reductions of mean 15
%K Mucoepidermoid carcinoma (Other)
%K carbon ion beam therapy (Other)
%K chemoradiation (Other)
%K head and neck (Other)
%K in vitro (Other)
%K ion beam therapy (Other)
%K particle beam therapy (Other)
%K radiotherapy (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37652498
%R 10.21873/invivo.13291
%U https://inrepo02.dkfz.de/record/282461