TY  - JOUR
AU  - Schneider, Thomas
AU  - Zwicker, Felix
AU  - Huber, Peter Ernst
AU  - Debus, Jürgen
AU  - Hauswald, Henrik
TI  - In Vitro Carbon Ion Beam and Gemcitabine Chemoradiation in a Mucoepidermoid Carcinoma Cell Line.
JO  - In vivo
VL  - 37
IS  - 5
SN  - 0258-851x
CY  - Kapandriti, Attiki
PB  - IIAR
M1  - DKFZ-2023-01776
SP  - 1951 - 1959
PY  - 2023
N1  - #EA:E055#LA:E055#
AB  - To determine the interaction of gemcitabine in chemoradiotherapy with heavy carbon ions in vitro in a mucoepidermoid carcinoma (MEC) cell line.The human lymphatic MEC metastasis cell line NCI-H292 was used. The cells were treated with photons, carbon ions, and gemcitabine. Survival fractions (SF), apoptosis, and cell cycle progression were analyzed. A paired two-sided t-test was used. Significance was defined as p<0.05.Cell proliferation assays showed a significant reduction in SF for combined photon chemoradiation versus photons only. The linear-quadratic fits of combined therapy with carbon ion dose of 0 to 2.5 Gy led to reductions of mean 15
KW  - Mucoepidermoid carcinoma (Other)
KW  - carbon ion beam therapy (Other)
KW  - chemoradiation (Other)
KW  - head and neck (Other)
KW  - in vitro (Other)
KW  - ion beam therapy (Other)
KW  - particle beam therapy (Other)
KW  - radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37652498
DO  - DOI:10.21873/invivo.13291
UR  - https://inrepo02.dkfz.de/record/282461
ER  -