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000282464 1001_ $$aDelbrouck, Catherine$$b0
000282464 245__ $$aFormate promotes invasion and metastasis in reliance on lipid metabolism.
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000282464 520__ $$aMetabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds the anabolic demand of cancer cells, resulting in formate overflow. Furthermore, we showed that increased extracellular formate concentrations promote the in vitro invasiveness of glioblastoma cells. Here, we substantiate these initial observations with ex vivo and in vivo experiments. We also show that exposure to exogeneous formate can prime cancer cells toward a pro-invasive phenotype leading to increased metastasis formation in vivo. Our results suggest that the increased local formate concentration within the tumor microenvironment can be one factor to promote metastases. Additionally, we describe a mechanistic interplay between formate-dependent increased invasiveness and adaptations of lipid metabolism and matrix metalloproteinase activity. Our findings consolidate the role of formate as pro-invasive metabolite and warrant further research to better understand the interplay between formate and lipid metabolism.
000282464 536__ $$0G:(DE-HGF)POF4-311$$a311 - Zellbiologie und Tumorbiologie (POF4-311)$$cPOF4-311$$fPOF IV$$x0
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000282464 650_7 $$2Other$$aCP: Cancer
000282464 650_7 $$2Other$$aCP: Metabolism
000282464 650_7 $$2Other$$acancer metastasis
000282464 650_7 $$2Other$$aformate overflow
000282464 650_7 $$2Other$$ainvasion
000282464 650_7 $$2Other$$aone-carbon metabolism
000282464 7001_ $$aKiweler, Nicole$$b1
000282464 7001_ $$aChen, Oleg$$b2
000282464 7001_ $$aPozdeev, Vitaly I$$b3
000282464 7001_ $$aHaase, Lara$$b4
000282464 7001_ $$aNeises, Laura$$b5
000282464 7001_ $$aOudin, Anaïs$$b6
000282464 7001_ $$aFouquier d'Hérouël, Aymeric$$b7
000282464 7001_ $$aShen, Ruolin$$b8
000282464 7001_ $$0P:(DE-He78)e52c8f6ae826320eaf2fb173e162070d$$aSchlicker, Lisa$$b9$$udkfz
000282464 7001_ $$aHalder, Rashi$$b10
000282464 7001_ $$aLesur, Antoine$$b11
000282464 7001_ $$aSchuster, Anne$$b12
000282464 7001_ $$0P:(DE-HGF)0$$aLorenz, Nadja I$$b13
000282464 7001_ $$aJaeger, Christian$$b14
000282464 7001_ $$aFeucherolles, Maureen$$b15
000282464 7001_ $$aFrache, Gilles$$b16
000282464 7001_ $$aSzpakowska, Martyna$$b17
000282464 7001_ $$aChevigne, Andy$$b18
000282464 7001_ $$0P:(DE-HGF)0$$aRonellenfitsch, Michael W$$b19
000282464 7001_ $$aMoussay, Etienne$$b20
000282464 7001_ $$aPiraud, Marie$$b21
000282464 7001_ $$aSkupin, Alexander$$b22
000282464 7001_ $$0P:(DE-He78)94ae391f53fb9285e1b68f9930615af1$$aSchulze, Almut$$b23$$udkfz
000282464 7001_ $$aNiclou, Simone P$$b24
000282464 7001_ $$aLetellier, Elisabeth$$b25
000282464 7001_ $$aMeiser, Johannes$$b26
000282464 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2023.113034$$gVol. 42, no. 9, p. 113034 -$$n9$$p113034$$tCell reports$$v42$$x2211-1247$$y2023
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