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@ARTICLE{Delbrouck:282464,
      author       = {C. Delbrouck and N. Kiweler and O. Chen and V. I. Pozdeev
                      and L. Haase and L. Neises and A. Oudin and A. Fouquier
                      d'Hérouël and R. Shen and L. Schlicker$^*$ and R. Halder
                      and A. Lesur and A. Schuster and N. I. Lorenz$^*$ and C.
                      Jaeger and M. Feucherolles and G. Frache and M. Szpakowska
                      and A. Chevigne and M. W. Ronellenfitsch$^*$ and E. Moussay
                      and M. Piraud and A. Skupin and A. Schulze$^*$ and S. P.
                      Niclou and E. Letellier and J. Meiser},
      title        = {{F}ormate promotes invasion and metastasis in reliance on
                      lipid metabolism.},
      journal      = {Cell reports},
      volume       = {42},
      number       = {9},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2023-01779},
      pages        = {113034},
      year         = {2023},
      abstract     = {Metabolic rewiring is essential for cancer onset and
                      progression. We previously showed that one-carbon
                      metabolism-dependent formate production often exceeds the
                      anabolic demand of cancer cells, resulting in formate
                      overflow. Furthermore, we showed that increased
                      extracellular formate concentrations promote the in vitro
                      invasiveness of glioblastoma cells. Here, we substantiate
                      these initial observations with ex vivo and in vivo
                      experiments. We also show that exposure to exogeneous
                      formate can prime cancer cells toward a pro-invasive
                      phenotype leading to increased metastasis formation in vivo.
                      Our results suggest that the increased local formate
                      concentration within the tumor microenvironment can be one
                      factor to promote metastases. Additionally, we describe a
                      mechanistic interplay between formate-dependent increased
                      invasiveness and adaptations of lipid metabolism and matrix
                      metalloproteinase activity. Our findings consolidate the
                      role of formate as pro-invasive metabolite and warrant
                      further research to better understand the interplay between
                      formate and lipid metabolism.},
      keywords     = {CP: Cancer (Other) / CP: Metabolism (Other) / cancer
                      metastasis (Other) / formate overflow (Other) / invasion
                      (Other) / one-carbon metabolism (Other)},
      cin          = {A410 / W120 / FM01},
      ddc          = {610},
      cid          = {I:(DE-He78)A410-20160331 / I:(DE-He78)W120-20160331 /
                      I:(DE-He78)FM01-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37651228},
      doi          = {10.1016/j.celrep.2023.113034},
      url          = {https://inrepo02.dkfz.de/record/282464},
}