TY  - JOUR
AU  - Löding, Sebastian
AU  - Andersson, Ulrika
AU  - Kaaks, Rudolf
AU  - Schulze, Matthias B
AU  - Pala, Valeria
AU  - Urbarova, Ilona
AU  - Amiano, Pilar
AU  - Colorado-Yohar, Sandra M
AU  - Guevara, Marcela
AU  - Heath, Alicia K
AU  - Chatziioannou, Anastasia Chrysovalantou
AU  - Johansson, Mattias
AU  - Nyberg, Lars
AU  - Antti, Henrik
AU  - Björkblom, Benny
AU  - Melin, Beatrice
TI  - Altered plasma metabolite levels can be detected years before a glioma diagnosis.
JO  - JCI insight
VL  - 8
IS  - 19
SN  - 2379-3708
CY  - Ann Arbor, Michigan
PB  - JCI Insight
M1  - DKFZ-2023-01780
SP  - e171225
PY  - 2023
N1  - 2023 Oct 9;8(19):e171225
AB  - Genetic and metabolic changes in tissue and blood are reported to occur several years before glioma diagnosis. As gliomas are currently detected late, a liquid biopsy for early detection could impact the quality of life and prognosis of patients. Here, we present a nested case-control study of 550 pre-diagnostic glioma cases and 550 healthy controls, from the Northern Sweden Health and Disease study (NSHDS) and the European Prospective Investigation into Cancer and Nutrition (EPIC) study. We identified 93 significantly altered metabolites related to glioma development up to eight years before diagnosis. Out of these metabolites, a panel of 20 selected metabolites showed strong disease correlation and consistent progression pattern towards diagnosis in both the NSHDS and EPIC cohorts, and separated favorably future cases from controls independently of biological sex. The blood metabolite panel also successfully separated both lower grade glioma and glioblastoma cases from controls, up to eight years before diagnosis in NSHDS (glioma AUC=0.85, P=3.1e-12; glioblastoma AUC=0.85, P=6.3e-8), and up to two years before diagnosis in EPIC (glioma AUC=0.81, P=0.005; glioblastoma AUC=0.89, P=0.04). Pathway enrichment analysis detected metabolites related to the TCA-cycle, Warburg effect, gluconeogenesis, cysteine-, pyruvate- and tyrosine metabolism as the most affected.
KW  - Brain cancer (Other)
KW  - Metabolism (Other)
KW  - Oncology (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37651185
DO  - DOI:10.1172/jci.insight.171225
UR  - https://inrepo02.dkfz.de/record/282465
ER  -