TY  - JOUR
AU  - Placke, Jan-Malte
AU  - Kimmig, Mona
AU  - Griewank, Klaus
AU  - Herbst, Rudolf
AU  - Terheyden, Patrick
AU  - Utikal, Jochen
AU  - Pföhler, Claudia
AU  - Ulrich, Jens
AU  - Kreuter, Alexander
AU  - Mohr, Peter
AU  - Gutzmer, Ralf
AU  - Meier, Friedegund
AU  - Dippel, Edgar
AU  - Welzel, Julia
AU  - Engel, Daniel Robert
AU  - Kreft, Sophia
AU  - Sucker, Antje
AU  - Lodde, Georg
AU  - Krefting, Frederik
AU  - Stoffels, Ingo
AU  - Klode, Joachim
AU  - Roesch, Alexander
AU  - Zimmer, Lisa
AU  - Livingstone, Elisabeth
AU  - Hadaschik, Eva
AU  - Becker, Jürgen
AU  - Weichenthal, Michael
AU  - Tasdogan, Alpaslan
AU  - Schadendorf, Dirk
AU  - Ugurel, Selma
TI  - Correlation of tumor PD-L1 expression in different tissue types and outcome of PD-1-based immunotherapy in metastatic melanoma - analysis of the DeCOG prospective multicenter cohort study ADOREG/TRIM.
JO  - EBioMedicine
VL  - 96
SN  - 2352-3964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2023-01806
SP  - 104774
PY  - 2023
AB  - PD-1-based immune checkpoint inhibition (ICI) is the major backbone of current melanoma therapy. Tumor PD-L1 expression represents one of few biomarkers predicting ICI therapy outcome. The objective of the present study was to systematically investigate whether the type of tumor tissue examined for PD-L1 expression has an impact on the correlation with ICI therapy outcome.Pre-treatment tumor tissue was collected within the prospective DeCOG cohort study ADOREG/TRIM (CA209-578; NCT05750511) between February 2014 and May 2020 from 448 consecutive patients who received PD-1-based ICI for non-resectable metastatic melanoma. The primary study endpoint was best overall response (BOR), secondary endpoints were progression-free (PFS) and overall survival (OS). All endpoints were correlated with tumor PD-L1 expression (quantified with clone 28-8; cutoff ≥5
KW  - Biomarker (Other)
KW  - Immune checkpoint inhibition (Other)
KW  - Melanoma (Other)
KW  - Therapy outcome (Other)
KW  - Tumor PD-L1 (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37660535
DO  - DOI:10.1016/j.ebiom.2023.104774
UR  - https://inrepo02.dkfz.de/record/282517
ER  -