TY  - JOUR
AU  - Nabbi, Arash
AU  - Beck, Pengbo
AU  - Delaidelli, Alberto
AU  - Oldridge, Derek A
AU  - Sudhaman, Sumedha
AU  - Zhu, Kelsey
AU  - Yang, S Y Cindy
AU  - Mulder, David T
AU  - Bruce, Jeffrey P
AU  - Paulson, Joseph N
AU  - Raman, Pichai
AU  - Zhu, Yuankun
AU  - Resnick, Adam C
AU  - Sorensen, Poul H
AU  - Sill, Martin
AU  - Brabetz, Sebastian
AU  - Lambo, Sander
AU  - Malkin, David
AU  - Johann, Pascal
AU  - Kool, Marcel
AU  - Jones, David
AU  - Pfister, Stefan
AU  - Jäger, Natalie
AU  - Pugh, Trevor J
TI  - Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours.
JO  - Genome medicine
VL  - 15
IS  - 1
SN  - 1756-994X
CY  - London
PB  - BioMed Central
M1  - DKFZ-2023-01833
SP  - 67
PY  - 2023
N1  - #EA:B062#
AB  - Cancer immunotherapies including immune checkpoint inhibitors and Chimeric Antigen Receptor (CAR) T-cell therapy have shown variable response rates in paediatric patients highlighting the need to establish robust biomarkers for patient selection. While the tumour microenvironment in adults has been widely studied to delineate determinants of immune response, the immune composition of paediatric solid tumours remains relatively uncharacterized calling for investigations to identify potential immune biomarkers.To inform immunotherapy approaches in paediatric cancers with embryonal origin, we performed an immunogenomic analysis of RNA-seq data from 925 treatment-naïve paediatric nervous system tumours (pedNST) spanning 12 cancer types from three publicly available data sets.Within pedNST, we uncovered four broad immune clusters: Paediatric Inflamed (10
KW  - CNS tumours (Other)
KW  - Immunogenomics (Other)
KW  - Neuroblastoma (Other)
KW  - Paediatric neuro-oncology (Other)
KW  - Tumour microenvironment (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37679810
DO  - DOI:10.1186/s13073-023-01219-x
UR  - https://inrepo02.dkfz.de/record/282687
ER  -