%0 Journal Article
%A Rein, Avigail
%A Geron, Ifat
%A Kugler, Eitan
%A Fishman, Hila
%A Gottlieb, Eyal
%A Abramovich, Ifat
%A Giladi, Amir
%A Amit, Ido
%A Mulet-Lazaro, Roger
%A Delwel, Ruud
%A Gröschel, Stefan
%A Levin-Zaidman, Smadar
%A Dezorella, Nili
%A Holdengreber, Vered
%A Rao, Tata Nageswara
%A Yacobovich, Joanne
%A Steinberg-Shemer, Orna
%A Huang, Qiu-Hua
%A Tan, Yun
%A Chen, Sai-Juan
%A Izraeli, Shai
%A Birger, Yehudit
%T Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency.
%J Haematologica
%V 108
%N 9
%@ 0390-6078
%C Pavia
%I Ferrata Storti Foundation
%M DKFZ-2023-01837
%P 2316-2330
%D 2023
%X Mono-allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), affecting more than 85
%K Child
%K Humans
%K Mice
%K Animals
%K GATA2 Deficiency: genetics
%K Myelodysplastic Syndromes: pathology
%K Leukemia, Myeloid, Acute: genetics
%K Leukemia, Myeloid, Acute: metabolism
%K Bone Marrow: pathology
%K Hematopoietic Stem Cells: metabolism
%K Cell Transformation, Neoplastic: genetics
%K Cell Transformation, Neoplastic: metabolism
%K GATA2 Transcription Factor: genetics
%K GATA2 Transcription Factor: metabolism
%K GATA2 Transcription Factor (NLM Chemicals)
%K GATA2 protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36475518
%2 pmc:PMC10483369
%R 10.3324/haematol.2022.279437
%U https://inrepo02.dkfz.de/record/282691