TY  - JOUR
AU  - Rein, Avigail
AU  - Geron, Ifat
AU  - Kugler, Eitan
AU  - Fishman, Hila
AU  - Gottlieb, Eyal
AU  - Abramovich, Ifat
AU  - Giladi, Amir
AU  - Amit, Ido
AU  - Mulet-Lazaro, Roger
AU  - Delwel, Ruud
AU  - Gröschel, Stefan
AU  - Levin-Zaidman, Smadar
AU  - Dezorella, Nili
AU  - Holdengreber, Vered
AU  - Rao, Tata Nageswara
AU  - Yacobovich, Joanne
AU  - Steinberg-Shemer, Orna
AU  - Huang, Qiu-Hua
AU  - Tan, Yun
AU  - Chen, Sai-Juan
AU  - Izraeli, Shai
AU  - Birger, Yehudit
TI  - Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency.
JO  - Haematologica
VL  - 108
IS  - 9
SN  - 0390-6078
CY  - Pavia
PB  - Ferrata Storti Foundation
M1  - DKFZ-2023-01837
SP  - 2316-2330
PY  - 2023
AB  - Mono-allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), affecting more than 85
KW  - Child
KW  - Humans
KW  - Mice
KW  - Animals
KW  - GATA2 Deficiency: genetics
KW  - Myelodysplastic Syndromes: pathology
KW  - Leukemia, Myeloid, Acute: genetics
KW  - Leukemia, Myeloid, Acute: metabolism
KW  - Bone Marrow: pathology
KW  - Hematopoietic Stem Cells: metabolism
KW  - Cell Transformation, Neoplastic: genetics
KW  - Cell Transformation, Neoplastic: metabolism
KW  - GATA2 Transcription Factor: genetics
KW  - GATA2 Transcription Factor: metabolism
KW  - GATA2 Transcription Factor (NLM Chemicals)
KW  - GATA2 protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36475518
C2  - pmc:PMC10483369
DO  - DOI:10.3324/haematol.2022.279437
UR  - https://inrepo02.dkfz.de/record/282691
ER  -