%0 Journal Article
%A Tschiderer, Lena
%A Peters, Sanne A E
%A van der Schouw, Yvonne T
%A van Westing, Anniek C
%A Tong, Tammy Y N
%A Willeit, Peter
%A Seekircher, Lisa
%A Moreno-Iribas, Conchi
%A Huerta, José María
%A Crous-Bou, Marta
%A Söderholm, Martin
%A Schulze, Matthias B
%A Johansson, Cecilia
%A Själander, Sara
%A Heath, Alicia K
%A Macciotta, Alessandra
%A Dahm, Christina C
%A Ibsen, Daniel B
%A Pala, Valeria
%A Mellemkjær, Lene
%A Burgess, Stephen
%A Wood, Angela
%A Kaaks, Rudolf
%A Katzke, Verena
%A Amiano, Pilar
%A Rodriguez-Barranco, Miguel
%A Engström, Gunnar
%A Weiderpass, Elisabete
%A Tjønneland, Anne
%A Halkjær, Jytte
%A Panico, Salvatore
%A Danesh, John
%A Butterworth, Adam
%A Onland-Moret, N Charlotte
%T Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women.
%J Journal of the American Heart Association
%V 12
%N 18
%@ 2047-9980
%C New York, NY
%I Association
%M DKFZ-2023-01845
%P e030280
%D 2023
%Z 2023 Sep 19;12(18):e030280
%X Background Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. Methods and Results We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study. A total of 204 244 postmenopausal women without a history of stroke at baseline were included (7883 from EPIC-CVD [5292 from the subcohort], 196 361 from the UK Biobank). Pooled mean baseline age was 58.9 years (SD, 5.8), and pooled mean age at menopause was 47.8 years (SD, 6.2). Over a median follow-up of 12.6 years (interquartile range, 11.8-13.3), 6770 women experienced a stroke (5155 ischemic strokes, 1615 hemorrhagic strokes, 976 intracerebral hemorrhages, and 639 subarachnoid hemorrhages). In multivariable adjusted observational Cox regression analyses, the pooled hazard ratios per 5 years younger age at menopause were 1.09 (95
%K Mendelian randomization analysis (Other)
%K age at menopause (Other)
%K observational analysis (Other)
%K stroke (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37681566
%R 10.1161/JAHA.123.030280
%U https://inrepo02.dkfz.de/record/282719