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000282719 1001_ $$00000-0001-7988-853X$$aTschiderer, Lena$$b0
000282719 245__ $$aAge at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women.
000282719 260__ $$aNew York, NY$$bAssociation$$c2023
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000282719 520__ $$aBackground Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. Methods and Results We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study. A total of 204 244 postmenopausal women without a history of stroke at baseline were included (7883 from EPIC-CVD [5292 from the subcohort], 196 361 from the UK Biobank). Pooled mean baseline age was 58.9 years (SD, 5.8), and pooled mean age at menopause was 47.8 years (SD, 6.2). Over a median follow-up of 12.6 years (interquartile range, 11.8-13.3), 6770 women experienced a stroke (5155 ischemic strokes, 1615 hemorrhagic strokes, 976 intracerebral hemorrhages, and 639 subarachnoid hemorrhages). In multivariable adjusted observational Cox regression analyses, the pooled hazard ratios per 5 years younger age at menopause were 1.09 (95% CI, 1.07-1.12) for stroke, 1.09 (95% CI, 1.06-1.13) for ischemic stroke, 1.10 (95% CI, 1.04-1.16) for hemorrhagic stroke, 1.14 (95% CI, 1.08-1.20) for intracerebral hemorrhage, and 1.00 (95% CI, 0.84-1.20) for subarachnoid hemorrhage. When using 2-sample Mendelian randomization analysis, we found no statistically significant association between genetically proxied age at menopause and risk of any type of stroke. Conclusions In our study, earlier age at menopause was related to a higher risk of stroke. We found no statistically significant association between genetically proxied age at menopause and risk of stroke, suggesting no causal relationship.
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000282719 650_7 $$2Other$$aMendelian randomization analysis
000282719 650_7 $$2Other$$aage at menopause
000282719 650_7 $$2Other$$aobservational analysis
000282719 650_7 $$2Other$$astroke
000282719 7001_ $$00000-0003-0346-5412$$aPeters, Sanne A E$$b1
000282719 7001_ $$00000-0002-4605-435X$$avan der Schouw, Yvonne T$$b2
000282719 7001_ $$avan Westing, Anniek C$$b3
000282719 7001_ $$00000-0002-0284-8959$$aTong, Tammy Y N$$b4
000282719 7001_ $$00000-0002-1866-7159$$aWilleit, Peter$$b5
000282719 7001_ $$aSeekircher, Lisa$$b6
000282719 7001_ $$00000-0001-6537-0131$$aMoreno-Iribas, Conchi$$b7
000282719 7001_ $$00000-0002-9637-3869$$aHuerta, José María$$b8
000282719 7001_ $$00000-0003-1493-4288$$aCrous-Bou, Marta$$b9
000282719 7001_ $$00009-0001-3129-9581$$aSöderholm, Martin$$b10
000282719 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b11
000282719 7001_ $$aJohansson, Cecilia$$b12
000282719 7001_ $$00000-0002-1239-6239$$aSjälander, Sara$$b13
000282719 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b14
000282719 7001_ $$00000-0002-0287-7979$$aMacciotta, Alessandra$$b15
000282719 7001_ $$00000-0003-0481-2893$$aDahm, Christina C$$b16
000282719 7001_ $$00000-0002-7038-4770$$aIbsen, Daniel B$$b17
000282719 7001_ $$00000-0001-5438-970X$$aPala, Valeria$$b18
000282719 7001_ $$aMellemkjær, Lene$$b19
000282719 7001_ $$00000-0001-5365-8760$$aBurgess, Stephen$$b20
000282719 7001_ $$00000-0002-7937-304X$$aWood, Angela$$b21
000282719 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b22$$udkfz
000282719 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b23$$udkfz
000282719 7001_ $$00000-0003-3986-7026$$aAmiano, Pilar$$b24
000282719 7001_ $$00000-0002-9972-9779$$aRodriguez-Barranco, Miguel$$b25
000282719 7001_ $$00000-0002-8618-9152$$aEngström, Gunnar$$b26
000282719 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b27
000282719 7001_ $$aTjønneland, Anne$$b28
000282719 7001_ $$aHalkjær, Jytte$$b29
000282719 7001_ $$aPanico, Salvatore$$b30
000282719 7001_ $$aDanesh, John$$b31
000282719 7001_ $$00000-0002-6915-9015$$aButterworth, Adam$$b32
000282719 7001_ $$00000-0002-2360-913X$$aOnland-Moret, N Charlotte$$b33
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