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@ARTICLE{Tschiderer:282719,
      author       = {L. Tschiderer and S. A. E. Peters and Y. T. van der Schouw
                      and A. C. van Westing and T. Y. N. Tong and P. Willeit and
                      L. Seekircher and C. Moreno-Iribas and J. M. Huerta and M.
                      Crous-Bou and M. Söderholm and M. B. Schulze and C.
                      Johansson and S. Själander and A. K. Heath and A. Macciotta
                      and C. C. Dahm and D. B. Ibsen and V. Pala and L.
                      Mellemkjær and S. Burgess and A. Wood and R. Kaaks$^*$ and
                      V. Katzke$^*$ and P. Amiano and M. Rodriguez-Barranco and G.
                      Engström and E. Weiderpass and A. Tjønneland and J.
                      Halkjær and S. Panico and J. Danesh and A. Butterworth and
                      N. C. Onland-Moret},
      title        = {{A}ge at {M}enopause and the {R}isk of {S}troke:
                      {O}bservational and {M}endelian {R}andomization {A}nalysis
                      in 204 244 {P}ostmenopausal {W}omen.},
      journal      = {Journal of the American Heart Association},
      volume       = {12},
      number       = {18},
      issn         = {2047-9980},
      address      = {New York, NY},
      publisher    = {Association},
      reportid     = {DKFZ-2023-01845},
      pages        = {e030280},
      year         = {2023},
      note         = {2023 Sep 19;12(18):e030280},
      abstract     = {Background Observational studies have shown that women with
                      an early menopause are at higher risk of stroke compared
                      with women with a later menopause. However, associations
                      with stroke subtypes are inconsistent, and the causality is
                      unclear. Methods and Results We analyzed data of the UK
                      Biobank and EPIC-CVD (European Prospective Investigation
                      Into Cancer and Nutrition-Cardiovascular Diseases) study. A
                      total of 204 244 postmenopausal women without a history of
                      stroke at baseline were included (7883 from EPIC-CVD [5292
                      from the subcohort], 196 361 from the UK Biobank). Pooled
                      mean baseline age was 58.9 years (SD, 5.8), and pooled mean
                      age at menopause was 47.8 years (SD, 6.2). Over a median
                      follow-up of 12.6 years (interquartile range, 11.8-13.3),
                      6770 women experienced a stroke (5155 ischemic strokes, 1615
                      hemorrhagic strokes, 976 intracerebral hemorrhages, and 639
                      subarachnoid hemorrhages). In multivariable adjusted
                      observational Cox regression analyses, the pooled hazard
                      ratios per 5 years younger age at menopause were 1.09
                      $(95\%$ CI, 1.07-1.12) for stroke, 1.09 $(95\%$ CI,
                      1.06-1.13) for ischemic stroke, 1.10 $(95\%$ CI, 1.04-1.16)
                      for hemorrhagic stroke, 1.14 $(95\%$ CI, 1.08-1.20) for
                      intracerebral hemorrhage, and 1.00 $(95\%$ CI, 0.84-1.20)
                      for subarachnoid hemorrhage. When using 2-sample Mendelian
                      randomization analysis, we found no statistically
                      significant association between genetically proxied age at
                      menopause and risk of any type of stroke. Conclusions In our
                      study, earlier age at menopause was related to a higher risk
                      of stroke. We found no statistically significant association
                      between genetically proxied age at menopause and risk of
                      stroke, suggesting no causal relationship.},
      keywords     = {Mendelian randomization analysis (Other) / age at menopause
                      (Other) / observational analysis (Other) / stroke (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37681566},
      doi          = {10.1161/JAHA.123.030280},
      url          = {https://inrepo02.dkfz.de/record/282719},
}