%0 Journal Article
%A Lam, Marnix
%A Garin, Etienne
%A Palard-Novello, Xavier
%A Mahvash, Armeen
%A Kappadath, Cheenu
%A Haste, Paul
%A Tann, Mark
%A Herrmann, Ken
%A Barbato, Francesco
%A Geller, Brian
%A Schaefer, Niklaus
%A Denys, Alban
%A Dreher, Matthew
%A Fowers, Kirk D
%A Gates, Vanessa
%A Salem, Riad
%T Direct comparison and reproducibility of two segmentation methods for multicompartment dosimetry: round robin study on radioembolization treatment planning in hepatocellular carcinoma.
%J European journal of nuclear medicine and molecular imaging
%V 51
%N 1
%@ 1619-7070
%C Heidelberg [u.a.]
%I Springer-Verl.
%M DKFZ-2023-01861
%P 245-257
%D 2023
%Z 2023 Dec;51(1):245-257
%X Investigate reproducibility of two segmentation methods for multicompartment dosimetry, including normal tissue absorbed dose (NTAD) and tumour absorbed dose (TAD), in hepatocellular carcinoma patients treated with yttrium-90 (90Y) glass microspheres.TARGET was a retrospective investigation in 209 patients with < 10 tumours per lobe and at least one tumour ≥ 3 cm ± portal vein thrombosis. Dosimetry was compared using two distinct segmentation methods: anatomic (CT/MRI-based) and count threshold-based on pre-procedural 99mTc-MAA SPECT. In a round robin substudy in 20 patients with ≤ 5 unilobar tumours, the inter-observer reproducibility of eight reviewers was evaluated by computing reproducibility coefficient (RDC) of volume and absorbed dose for whole liver, whole liver normal tissue, perfused normal tissue, perfused liver, total perfused tumour, and target lesion. Intra-observer reproducibility was based on second assessments in 10 patients ≥ 2 weeks later.99mTc-MAA segmentation calculated higher absorbed doses compared to anatomic segmentation (n = 209), 43.9
%K Dosimetry (Other)
%K Hepatocellular carcinoma (Other)
%K Radioembolization (Other)
%K Yttrium-90 (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37698645
%R 10.1007/s00259-023-06416-9
%U https://inrepo02.dkfz.de/record/282738