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@ARTICLE{Lam:282738,
      author       = {M. Lam and E. Garin and X. Palard-Novello and A. Mahvash
                      and C. Kappadath and P. Haste and M. Tann and K.
                      Herrmann$^*$ and F. Barbato$^*$ and B. Geller and N.
                      Schaefer and A. Denys and M. Dreher and K. D. Fowers and V.
                      Gates and R. Salem},
      title        = {{D}irect comparison and reproducibility of two segmentation
                      methods for multicompartment dosimetry: round robin study on
                      radioembolization treatment planning in hepatocellular
                      carcinoma.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {51},
      number       = {1},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DKFZ-2023-01861},
      pages        = {245-257},
      year         = {2023},
      note         = {2023 Dec;51(1):245-257},
      abstract     = {Investigate reproducibility of two segmentation methods for
                      multicompartment dosimetry, including normal tissue absorbed
                      dose (NTAD) and tumour absorbed dose (TAD), in
                      hepatocellular carcinoma patients treated with yttrium-90
                      (90Y) glass microspheres.TARGET was a retrospective
                      investigation in 209 patients with < 10 tumours per lobe and
                      at least one tumour ≥ 3 cm ± portal vein thrombosis.
                      Dosimetry was compared using two distinct segmentation
                      methods: anatomic (CT/MRI-based) and count threshold-based
                      on pre-procedural 99mTc-MAA SPECT. In a round robin substudy
                      in 20 patients with ≤ 5 unilobar tumours, the
                      inter-observer reproducibility of eight reviewers was
                      evaluated by computing reproducibility coefficient (RDC) of
                      volume and absorbed dose for whole liver, whole liver normal
                      tissue, perfused normal tissue, perfused liver, total
                      perfused tumour, and target lesion. Intra-observer
                      reproducibility was based on second assessments in 10
                      patients ≥ 2 weeks later.99mTc-MAA segmentation calculated
                      higher absorbed doses compared to anatomic segmentation (n =
                      209), $43.9\%$ higher for TAD $(95\%$ limits of agreement
                      [LoA]: - $49.0\%,$ $306.2\%)$ and $21.3\%$ for NTAD $(95\%$
                      LoA: - $67.6\%,$ $354.0\%).$ For the round robin substudy (n
                      = 20), inter-observer reproducibility was better for
                      anatomic (RDC range: 1.17 to 3.53) than 99mTc-MAA SPECT
                      segmentation (1.29 to 7.00) and similar between anatomic
                      imaging modalities (CT: 1.09 to 3.56; MRI: 1.24 to 3.50).
                      Inter-observer reproducibility was better for larger
                      volumes. Perfused normal tissue volume RDC was 1.95 by
                      anatomic and 3.19 by 99mTc-MAA SPECT, with corresponding
                      absorbed dose RDC 1.46 and 1.75. Total perfused tumour
                      volume RDC was higher, 2.92 for anatomic and 7.0 by
                      99mTc-MAA SPECT with corresponding absorbed dose RDC of 1.84
                      and 2.78. Intra-observer variability was lower for perfused
                      NTAD (range: 14.3 to 19.7 Gy) than total perfused TAD
                      (range: 42.8 to 121.4 Gy).Anatomic segmentation-based
                      dosimetry, versus 99mTc-MAA segmentation, results in lower
                      absorbed doses with superior reproducibility. Higher volume
                      compartments, such as normal tissue versus tumour, exhibit
                      improved reproducibility.NCT03295006.},
      keywords     = {Dosimetry (Other) / Hepatocellular carcinoma (Other) /
                      Radioembolization (Other) / Yttrium-90 (Other)},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37698645},
      doi          = {10.1007/s00259-023-06416-9},
      url          = {https://inrepo02.dkfz.de/record/282738},
}