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@ARTICLE{Hoffmann:282756,
      author       = {I. Hoffmann and M. P. Dragomir$^*$ and N. Monjé and C.
                      Keunecke and C. A. Kunze and S. Schallenberg and S.
                      Marchenko and W. D. Schmitt and H. Kulbe and J. Sehouli and
                      I. E. Braicu and P. Jank and C. Denkert and S. Darb-Esfahani
                      and D. Horst and B. V. Sinn and C. Sers and P. Bischoff$^*$
                      and E. T. Taube},
      title        = {{I}ncreased expression of {IDO}1 is associated with
                      improved survival and increased number of {TIL}s in patients
                      with high-grade serous ovarian cancer.},
      journal      = {Neoplasia},
      volume       = {44},
      issn         = {1522-8002},
      address      = {Basingstoke},
      publisher    = {Stockton Press},
      reportid     = {DKFZ-2023-01875},
      pages        = {100934},
      year         = {2023},
      abstract     = {The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays a
                      crucial role in regulating the immune system's response to
                      tumors, but its exact role in cancer, especially in
                      high-grade serous ovarian cancer (HGSOC), remains
                      controversial. We aimed to investigate the prognostic impact
                      of IDO1 expression and its correlation with
                      tumor-infiltrating lymphocytes (TILs) in
                      HGSOC.Immunohistochemical (IHC) staining and bioimage
                      analysis using the QuPath software were employed to assess
                      IDO1 protein expression in a well-characterized cohort of
                      507 patients with primary HGSOC. Statistical evaluation was
                      performed using SPSS, and in silico validation considering
                      IDO1 mRNA expression in bulk and single-cell gene expression
                      datasets was conducted. Additionally, IDO1 expression in
                      interferon-gamma (IFNG) stimulated HGSOC cell lines was
                      analyzed.Our findings revealed that IDO1 protein and mRNA
                      expression serve as positive prognostic markers for overall
                      survival (OS) and progression-free survival (PFS) in HGSOC.
                      High IDO1 expression was associated with a significant
                      improvement in OS by 21 months (p < 0.001) and PFS by 6
                      months (p = 0.016). Notably, elevated IDO1 expression
                      correlated with an increased number of CD3+ (p < 0.001),
                      CD4+ (p < 0.001), and CD8+ TILs (p < 0.001). Furthermore,
                      high IDO1 mRNA expression and protein level were found to be
                      associated with enhanced responsiveness to pro-inflammatory
                      cytokines, particularly IFNG.Our study provides evidence
                      that IDO1 expression serves as a positive prognostic marker
                      in HGSOC and is associated with an increased number of CD3+,
                      CD4+ and CD8+ TILs. Understanding the intricate relationship
                      between IDO1, TILs, and the tumor microenvironment may hold
                      the key to improving outcomes in HGSOC.},
      keywords     = {HGSOC (Other) / IDO1 (Other) / Ovarian cancer (Other) /
                      Prognostic marker (Other) / TILs (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37703626},
      doi          = {10.1016/j.neo.2023.100934},
      url          = {https://inrepo02.dkfz.de/record/282756},
}