TY  - JOUR
AU  - Delaunay, Sylvain
AU  - Helm, Mark
AU  - Frye, Michaela
TI  - RNA modifications in physiology and disease: towards clinical applications.
JO  - Nature reviews / Genetics
VL  - 25
IS  - 2
SN  - 1471-0056
CY  - London
PB  - Nature Publ. Group
M1  - DKFZ-2023-01892
SP  - 104-122
PY  - 2024
N1  - #EA:A350#LA:A350# / 2024 Feb;25(2):104-122
AB  - The ability of chemical modifications of single nucleotides to alter the electrostatic charge, hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of stable artificial RNAs such as mRNA vaccines and synthetic small RNA molecules - to increase or decrease the expression of therapeutic proteins. Furthermore, naturally occurring biochemical modifications of nucleotides regulate RNA metabolism and function to modulate crucial cellular processes. Studies showing the mechanisms by which RNA modifications regulate basic cell functions in higher organisms have led to greater understanding of how aberrant RNA modification profiles can cause disease in humans. Together, these basic science discoveries have unravelled the molecular and cellular functions of RNA modifications, have provided new prospects for therapeutic manipulation and have led to a range of innovative clinical approaches.
LB  - PUB:(DE-HGF)16
C6  - pmid:37714958
DO  - DOI:10.1038/s41576-023-00645-2
UR  - https://inrepo02.dkfz.de/record/282899
ER  -