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@ARTICLE{Delaunay:282899,
      author       = {S. Delaunay$^*$ and M. Helm and M. Frye$^*$},
      title        = {{RNA} modifications in physiology and disease: towards
                      clinical applications.},
      journal      = {Nature reviews / Genetics},
      volume       = {25},
      number       = {2},
      issn         = {1471-0056},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2023-01892},
      pages        = {104-122},
      year         = {2024},
      note         = {#EA:A350#LA:A350# / 2024 Feb;25(2):104-122},
      abstract     = {The ability of chemical modifications of single nucleotides
                      to alter the electrostatic charge, hydrophobic surface and
                      base pairing of RNA molecules is exploited for the clinical
                      use of stable artificial RNAs such as mRNA vaccines and
                      synthetic small RNA molecules - to increase or decrease the
                      expression of therapeutic proteins. Furthermore, naturally
                      occurring biochemical modifications of nucleotides regulate
                      RNA metabolism and function to modulate crucial cellular
                      processes. Studies showing the mechanisms by which RNA
                      modifications regulate basic cell functions in higher
                      organisms have led to greater understanding of how aberrant
                      RNA modification profiles can cause disease in humans.
                      Together, these basic science discoveries have unravelled
                      the molecular and cellular functions of RNA modifications,
                      have provided new prospects for therapeutic manipulation and
                      have led to a range of innovative clinical approaches.},
      subtyp        = {Review Article},
      cin          = {A350},
      ddc          = {570},
      cid          = {I:(DE-He78)A350-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37714958},
      doi          = {10.1038/s41576-023-00645-2},
      url          = {https://inrepo02.dkfz.de/record/282899},
}