%0 Journal Article
%A Lauer, Eliza M
%A Riegler, Ella
%A Mutter, Jurik A
%A Alig, Stefan K
%A Bleul, Sabine
%A Kuehn, Julia
%A Ranganathan, Lavanya
%A Klingler, Christian
%A Demerath, Theo
%A Würtemberger, Urs
%A Rau, Alexander
%A Weiß, Jakob
%A Eisenblaetter, Michel
%A Bamberg, Fabian
%A Prinz, Marco
%A Finke, Jürgen
%A Duyster, Justus
%A Illerhaus, Gerald
%A Diehn, Maximilian
%A Alizadeh, Ash A
%A Schorb, Elisabeth
%A Reinacher, Peter C
%A Scherer, Florian
%T Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas.
%J Neuro-Oncology
%V 26
%N 2
%@ 1522-8517
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2023-01893
%P  374–386
%D 2024
%Z 26(2), pp. 374–386, 2024
%X Central nervous system lymphomas (CNSL) display remarkable clinical heterogeneity, yet accurate prediction of outcomes remains challenging. The IPCG criteria are widely used in routine practice for the assessment of treatment response. However, the value of the IPCG criteria for ultimate outcome prediction is largely unclear, mainly due to the uncertainty in delineating complete from partial responses during and after treatment.We explored various MRI features including semi-automated 3D tumor volume measurements at different disease milestones and their association with survival in 93 CNSL patients undergoing curative-intent treatment.At diagnosis, patients with more than three lymphoma lesions, periventricular involvement, and high 3D tumor volumes showed significantly unfavorable PFS and OS. At first interim MRI during treatment, the IPCG criteria failed to discriminate outcomes in responding patients. Therefore, we randomized these patients into training and validation cohorts to investigate whether 3D tumor volumetry could improve outcome prediction. We identified a 3D tumor volume reduction of ≥97
%K CNS lymphoma (Other)
%K Circulating tumor DNA (Other)
%K Composite biomarker (Other)
%K Improved early outcome prediction (Other)
%K MRI-based 3D volumetry (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37713267
%R 10.1093/neuonc/noad177
%U https://inrepo02.dkfz.de/record/282900