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@ARTICLE{Schott:283130,
      author       = {A. Schott and A. Kluttig and R. Mikolajczyk and A.
                      Großkopf and K. H. Greiser$^*$ and K. Werdan and D. Sedding
                      and S. Nuding},
      title        = {{A}ssociation of subendocardial viability ratio and
                      mortality in the elderly population: results from the
                      {CAR}diovascular disease, {L}iving and {A}geing in {H}alle
                      study.},
      journal      = {Journal of hypertension},
      volume       = {42},
      number       = {2},
      issn         = {0263-6352},
      address      = {London},
      publisher    = {Lippincott, Williams $\&$ Wilkins},
      reportid     = {DKFZ-2023-01917},
      pages        = {371-376},
      year         = {2024},
      note         = {2024 Feb 1;42(2):371-376},
      abstract     = {The subendocardial viability ratio (SEVR) reflects the
                      balance of myocardial oxygen supply and demand. Low SEVR
                      indicates a reduced subendocardial perfusion and has been
                      shown to predict mortality in patients with kidney disease
                      and diabetes. The aim of this study is to investigate the
                      association of SEVR and mortality in the elderly
                      population.We analysed data from the CARdiovascular disease,
                      Living and Ageing in Halle (CARLA) study. SEVR was estimated
                      noninvasively by radial artery tonometry and brachial blood
                      pressure measurement. The study population was divided into
                      a low (SEVR $≤130\%)$ and normal (SEVR $>130\%)$ SEVR
                      group. Cox-regression was used for survival analysis.In
                      total, 1414 participants (635 women, 779 men) aged from 50
                      to 87 years (mean age 67.3 years) were included in the
                      analysis. The all-cause mortality was $22.7\%$ during a
                      median follow-up of 10.5 years. The unadjusted association
                      of SEVR with all-cause mortality decreased from 3.52
                      (1.31-9.46) [hazard ratio $(95\%$ confidence interval) for
                      low SEVR ≤ $130\%$ versus normal SEVR > $130\%]$ among
                      those younger than 60 years to 0.86 (0.50-1.48) among those
                      older than 80 years and from 1.81 (0.22-14.70) to 0.75
                      (0.30-1.91) for cardiovascular mortality. Sex-specific
                      unadjusted analyses demonstrated an association of SEVR with
                      all-cause and cardiovascular mortality in men [2.32
                      (1.61-3.34) and 2.24 (1.18-4.24)], but not in women [1.53
                      (0.87-2.72) and 1.14 (0.34-3.82)].Our data suggests that
                      SEVR is an age dependent predictor for all-cause mortality,
                      predominantly in men younger than 60 years.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37732518},
      doi          = {10.1097/HJH.0000000000003579},
      url          = {https://inrepo02.dkfz.de/record/283130},
}