%0 Journal Article
%A Ebersberger, Louise
%A Kratzer, Fabian J
%A Franke, Vanessa L
%A Nagel, Armin M
%A Niesporek, Sebastian
%A Korzowski, Andreas
%A Ladd, Mark E
%A Schlemmer, Heinz-Peter
%A Paech, Daniel
%A Platt, Tanja
%T First implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain.
%J Magnetic resonance materials in physics, biology and medicine
%V 37
%N 1
%@ 0968-5243
%C Heidelberg
%I Springer
%M DKFZ-2023-01924
%P 27-38
%D 2024
%Z #EA:E010#LA:E020# / 2024 Feb;37(1):27-38
%X First implementation of dynamic oxygen-17 (17O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain.Five healthy volunteers underwent a three-phase 17O gas (17O2) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute 17O water (H217O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm.The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of 17O MR data resulted in high signal fluctuations with a noise level of 10
%K Cerebral oxygen metabolism (Other)
%K Dynamic oxygen-17 imaging (Other)
%K Neuronal activity (Other)
%K Ultrahigh field MRI (Other)
%K fMRI (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37737942
%R 10.1007/s10334-023-01119-6
%U https://inrepo02.dkfz.de/record/283137