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000283137 1001_ $$0P:(DE-He78)59a36eaf1a3396a5962ba21c7b3150f8$$aEbersberger, Louise$$b0$$eFirst author$$udkfz
000283137 245__ $$aFirst implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain.
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000283137 500__ $$a#EA:E010#LA:E020# / 2024 Feb;37(1):27-38
000283137 520__ $$aFirst implementation of dynamic oxygen-17 (17O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain.Five healthy volunteers underwent a three-phase 17O gas (17O2) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute 17O water (H217O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm.The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of 17O MR data resulted in high signal fluctuations with a noise level of 10% due to small regions of interest (ROI), impeding further quantitative analysis. Statistical evaluation of the relative H217O signal with PV correction (p = 0.168) and without (p = 0.382) did not show significant difference between the stimulated left and non-stimulated right sensorimotor ROI.The change of cerebral oxygen metabolism induced by sensorimotor and visual stimulation is not large enough to be reliably detected with the current setup and methodology of dynamic 17O MRI at 7 T.
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000283137 650_7 $$2Other$$aCerebral oxygen metabolism
000283137 650_7 $$2Other$$aDynamic oxygen-17 imaging
000283137 650_7 $$2Other$$aNeuronal activity
000283137 650_7 $$2Other$$aUltrahigh field MRI
000283137 650_7 $$2Other$$afMRI
000283137 7001_ $$0P:(DE-He78)0ad4af74a6b337e282ad0281595593bc$$aKratzer, Fabian J$$b1$$udkfz
000283137 7001_ $$0P:(DE-He78)aa7c5ddf01ae4204a9724ad52583db88$$aFranke, Vanessa L$$b2$$udkfz
000283137 7001_ $$0P:(DE-He78)054fd7a5195b75b11fbdc5c360276011$$aNagel, Armin M$$b3$$udkfz
000283137 7001_ $$0P:(DE-He78)96512bceb234fc9ec15569396cbc3a34$$aNiesporek, Sebastian$$b4
000283137 7001_ $$0P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e$$aKorzowski, Andreas$$b5$$udkfz
000283137 7001_ $$0P:(DE-He78)022611a2317e4de40fd912e0a72293a8$$aLadd, Mark E$$b6$$udkfz
000283137 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b7$$udkfz
000283137 7001_ $$0P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc$$aPaech, Daniel$$b8$$udkfz
000283137 7001_ $$0P:(DE-He78)3c42114fa37390cfdc976bf0a9fcfb67$$aPlatt, Tanja$$b9$$eLast author$$udkfz
000283137 773__ $$0PERI:(DE-600)1502491-X$$a10.1007/s10334-023-01119-6$$n1$$p27-38$$tMagnetic resonance materials in physics, biology and medicine$$v37$$x0968-5243$$y2024
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