TY  - JOUR
AU  - Ebersberger, Louise
AU  - Kratzer, Fabian J
AU  - Franke, Vanessa L
AU  - Nagel, Armin M
AU  - Niesporek, Sebastian
AU  - Korzowski, Andreas
AU  - Ladd, Mark E
AU  - Schlemmer, Heinz-Peter
AU  - Paech, Daniel
AU  - Platt, Tanja
TI  - First implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain.
JO  - Magnetic resonance materials in physics, biology and medicine
VL  - 37
IS  - 1
SN  - 0968-5243
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2023-01924
SP  - 27-38
PY  - 2024
N1  - #EA:E010#LA:E020# / 2024 Feb;37(1):27-38
AB  - First implementation of dynamic oxygen-17 (17O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain.Five healthy volunteers underwent a three-phase 17O gas (17O2) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute 17O water (H217O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm.The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of 17O MR data resulted in high signal fluctuations with a noise level of 10
KW  - Cerebral oxygen metabolism (Other)
KW  - Dynamic oxygen-17 imaging (Other)
KW  - Neuronal activity (Other)
KW  - Ultrahigh field MRI (Other)
KW  - fMRI (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37737942
DO  - DOI:10.1007/s10334-023-01119-6
UR  - https://inrepo02.dkfz.de/record/283137
ER  -