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@ARTICLE{Ebersberger:283137,
      author       = {L. Ebersberger$^*$ and F. J. Kratzer$^*$ and V. L.
                      Franke$^*$ and A. M. Nagel$^*$ and S. Niesporek$^*$ and A.
                      Korzowski$^*$ and M. E. Ladd$^*$ and H.-P. Schlemmer$^*$ and
                      D. Paech$^*$ and T. Platt$^*$},
      title        = {{F}irst implementation of dynamic oxygen-17 (17{O})
                      magnetic resonance imaging at 7 {T}esla during neuronal
                      stimulation in the human brain.},
      journal      = {Magnetic resonance materials in physics, biology and
                      medicine},
      volume       = {37},
      number       = {1},
      issn         = {0968-5243},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2023-01924},
      pages        = {27-38},
      year         = {2024},
      note         = {#EA:E010#LA:E020# / 2024 Feb;37(1):27-38},
      abstract     = {First implementation of dynamic oxygen-17 (17O) MRI at 7
                      Tesla (T) during neuronal stimulation in the human
                      brain.Five healthy volunteers underwent a three-phase 17O
                      gas (17O2) inhalation experiment. Combined right-side visual
                      stimulus and right-hand finger tapping were used to achieve
                      neuronal stimulation in the left cerebral hemisphere. Data
                      analysis included the evaluation of the relative partial
                      volume (PV)-corrected time evolution of absolute 17O water
                      (H217O) concentration and of the relative signal evolution
                      without PV correction. Statistical analysis was performed
                      using a one-tailed paired t test. Blood oxygen
                      level-dependent (BOLD) experiments were performed to
                      validate the stimulation paradigm.The BOLD maps showed
                      significant activity in the stimulated left visual and
                      sensorimotor cortex compared to the non-stimulated right
                      side. PV correction of 17O MR data resulted in high signal
                      fluctuations with a noise level of $10\%$ due to small
                      regions of interest (ROI), impeding further quantitative
                      analysis. Statistical evaluation of the relative H217O
                      signal with PV correction (p = 0.168) and without (p =
                      0.382) did not show significant difference between the
                      stimulated left and non-stimulated right sensorimotor
                      ROI.The change of cerebral oxygen metabolism induced by
                      sensorimotor and visual stimulation is not large enough to
                      be reliably detected with the current setup and methodology
                      of dynamic 17O MRI at 7 T.},
      keywords     = {Cerebral oxygen metabolism (Other) / Dynamic oxygen-17
                      imaging (Other) / Neuronal activity (Other) / Ultrahigh
                      field MRI (Other) / fMRI (Other)},
      cin          = {E010 / E020},
      ddc          = {530},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37737942},
      doi          = {10.1007/s10334-023-01119-6},
      url          = {https://inrepo02.dkfz.de/record/283137},
}