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| 001 | 283137 | ||
| 005 | 20240304140811.0 | ||
| 024 | 7 | _ | |a 10.1007/s10334-023-01119-6 |2 doi |
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| 024 | 7 | _ | |a 0968-5243 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2023-01924 |
| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Ebersberger, Louise |0 P:(DE-He78)59a36eaf1a3396a5962ba21c7b3150f8 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a First implementation of dynamic oxygen-17 (17O) magnetic resonance imaging at 7 Tesla during neuronal stimulation in the human brain. |
| 260 | _ | _ | |a Heidelberg |c 2024 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1709557651_15777 |2 PUB:(DE-HGF) |
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| 500 | _ | _ | |a #EA:E010#LA:E020# / 2024 Feb;37(1):27-38 |
| 520 | _ | _ | |a First implementation of dynamic oxygen-17 (17O) MRI at 7 Tesla (T) during neuronal stimulation in the human brain.Five healthy volunteers underwent a three-phase 17O gas (17O2) inhalation experiment. Combined right-side visual stimulus and right-hand finger tapping were used to achieve neuronal stimulation in the left cerebral hemisphere. Data analysis included the evaluation of the relative partial volume (PV)-corrected time evolution of absolute 17O water (H217O) concentration and of the relative signal evolution without PV correction. Statistical analysis was performed using a one-tailed paired t test. Blood oxygen level-dependent (BOLD) experiments were performed to validate the stimulation paradigm.The BOLD maps showed significant activity in the stimulated left visual and sensorimotor cortex compared to the non-stimulated right side. PV correction of 17O MR data resulted in high signal fluctuations with a noise level of 10% due to small regions of interest (ROI), impeding further quantitative analysis. Statistical evaluation of the relative H217O signal with PV correction (p = 0.168) and without (p = 0.382) did not show significant difference between the stimulated left and non-stimulated right sensorimotor ROI.The change of cerebral oxygen metabolism induced by sensorimotor and visual stimulation is not large enough to be reliably detected with the current setup and methodology of dynamic 17O MRI at 7 T. |
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| 650 | _ | 7 | |a Cerebral oxygen metabolism |2 Other |
| 650 | _ | 7 | |a Dynamic oxygen-17 imaging |2 Other |
| 650 | _ | 7 | |a Neuronal activity |2 Other |
| 650 | _ | 7 | |a Ultrahigh field MRI |2 Other |
| 650 | _ | 7 | |a fMRI |2 Other |
| 700 | 1 | _ | |a Kratzer, Fabian J |0 P:(DE-He78)0ad4af74a6b337e282ad0281595593bc |b 1 |u dkfz |
| 700 | 1 | _ | |a Franke, Vanessa L |0 P:(DE-He78)aa7c5ddf01ae4204a9724ad52583db88 |b 2 |u dkfz |
| 700 | 1 | _ | |a Nagel, Armin M |0 P:(DE-He78)054fd7a5195b75b11fbdc5c360276011 |b 3 |u dkfz |
| 700 | 1 | _ | |a Niesporek, Sebastian |0 P:(DE-He78)96512bceb234fc9ec15569396cbc3a34 |b 4 |
| 700 | 1 | _ | |a Korzowski, Andreas |0 P:(DE-He78)577a5c61f44b8023e229610afbc7cd4e |b 5 |u dkfz |
| 700 | 1 | _ | |a Ladd, Mark E |0 P:(DE-He78)022611a2317e4de40fd912e0a72293a8 |b 6 |u dkfz |
| 700 | 1 | _ | |a Schlemmer, Heinz-Peter |0 P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec |b 7 |u dkfz |
| 700 | 1 | _ | |a Paech, Daniel |0 P:(DE-He78)c6e31fb8f19e185e254174554a0cccfc |b 8 |u dkfz |
| 700 | 1 | _ | |a Platt, Tanja |0 P:(DE-He78)3c42114fa37390cfdc976bf0a9fcfb67 |b 9 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1007/s10334-023-01119-6 |0 PERI:(DE-600)1502491-X |n 1 |p 27-38 |t Magnetic resonance materials in physics, biology and medicine |v 37 |y 2024 |x 0968-5243 |
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