%0 Journal Article
%A Muench, Amos
%A Teichmann, Daniel
%A Spille, Dorothee
%A Kuzman, Peter
%A Perez, Eilis
%A May, Sven-Axel
%A Mueller, Wolf C
%A Kombos, Theodoros
%A Nazari-Dehkordi, Shokufe
%A Onken, Julia
%A Vajkoczy, Peter
%A Ntoulias, Georgios
%A Bettencourt, Conceição
%A von Deimling, Andreas
%A Paulus, Werner
%A Heppner, Frank L
%A Koch, Arend
%A Capper, David
%A Kaul, David
%A Thomas, Christian
%A Schweizer, Leonille
%T A Novel Type of IDH Wild-type Glioma Characterized by Gliomatosis Cerebri-like Growth Pattern, TERT Promoter Mutation, and Distinct Epigenetic Profile.
%J The American journal of surgical pathology
%V 47
%N 12
%@ 0147-5185
%C [Erscheinungsort nicht ermittelbar]
%I Ovid
%M DKFZ-2023-01925
%P 1364-1375
%D 2023
%Z 2023 Dec 1;47(12):1364-1375
%X Diffuse gliomas in adults encompass a heterogenous group of central nervous system neoplasms. In recent years, extensive (epi-)genomic profiling has identified several glioma subgroups characterized by distinct molecular characteristics, most importantly IDH1/2 and histone H3 mutations. A group of 16 diffuse gliomas classified as 'adult-type diffuse high-grade glioma, IDH-wildtype, subtype F (HGG-F)' was identified by the DKFZ v12.5 Brain Tumor Classifier. Histopathologic characterization, exome sequencing, and review of clinical data was performed in all cases. Based on unsupervised t-distributed stochastic neighbor embedding and clustering analysis of genome-wide DNA methylation data, HGG-F shows distinct epigenetic profiles separate from established central nervous system tumors. Exome sequencing demonstrated frequent TERT promoter (12/15 cases), PIK3R1 (11/16), and TP53 mutations (5/16). Radiologic characteristics were reminiscent of gliomatosis cerebri in 9/14 cases (64
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37737691
%R 10.1097/PAS.0000000000002118
%U https://inrepo02.dkfz.de/record/283138