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@ARTICLE{Zhang:283140,
      author       = {J. Zhang and Y. Feng and G. Li and J. Zhang and X. Zhang
                      and Y. Zhang and Z. Qin and D. Zhuang and T. Qiu and Z. Shi
                      and W. Zhu and R. Zhang and Y. Wu and H. Liu$^*$ and D. Cao
                      and W. Hua and Y. Mao},
      title        = {{D}istinct aneuploid evolution of astrocytoma and
                      glioblastoma during recurrence.},
      journal      = {npj precision oncology},
      volume       = {7},
      number       = {1},
      issn         = {2397-768X},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2023-01927},
      pages        = {97},
      year         = {2023},
      note         = {DKFZ-ZMBH Alliance},
      abstract     = {Astrocytoma and glioblastoma (GB) are reclassified subtypes
                      of adult diffuse gliomas based on distinct isocitrate
                      dehydrogenase (IDH) mutation in the fifth edition of the WHO
                      Classification of Tumors of the Central Nervous System. The
                      recurrence of gliomas is a common and inevitable challenge,
                      and analyzing the distinct genomic alterations in
                      astrocytoma and GB could provide insights into their
                      progression. This study conducted a longitudinal
                      investigation, utilizing whole-exome sequencing, on 65
                      paired primary/recurrent gliomas. It examined chromosome arm
                      aneuploidies, copy number variations (CNVs) of
                      cancer-related genes and pathway enrichments during the
                      relapse. The veracity of these findings was verified through
                      the integration of our data with multiple public resources
                      and by corroborative immunohistochemistry (IHC). The results
                      revealed a greater prevalence of aneuploidy changes and
                      acquired CNVs in recurrent lower grade astrocytoma than in
                      relapsed grade 4 astrocytoma and GB. Larger aneuploidy
                      changes were predictive of an unfavorable prognosis in lower
                      grade astrocytoma (P < 0.05). Further, patients with
                      acquired gains of 1q, 6p or loss of 13q at recurrence had a
                      shorter overall survival in lower grade astrocytoma (P <
                      0.05); however, these prognostic effects were confined in
                      grade 4 astrocytoma and GB. Moreover, acquired gains of 12
                      genes (including VEGFA) on 6p during relapse were associated
                      with unfavorable prognosis for lower grade astrocytoma
                      patients. Notably, elevated VEGFA expression during
                      recurrence corresponded to poorer survival, validated
                      through IHC and CGGA data. To summarize, these findings
                      offer valuable insights into the progression of gliomas and
                      have implications for guiding therapeutic approaches during
                      recurrence.},
      cin          = {A240},
      ddc          = {610},
      cid          = {I:(DE-He78)A240-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37741941},
      pmc          = {pmc:PMC10517995},
      doi          = {10.1038/s41698-023-00453-1},
      url          = {https://inrepo02.dkfz.de/record/283140},
}