TY  - JOUR
AU  - Singer, Susanne
AU  - Semrau, Sabine
AU  - Golcher, Henriette
AU  - Fechner, Katja
AU  - Kallies, Annett
AU  - Zapata Bonilla, Sergio
AU  - Grützmann, Robert
AU  - Fietkau, Rainer
AU  - Kluba, Torsten
AU  - Jentsch, Christina
AU  - Andreou, Dimosthenis
AU  - Bornhäuser, Martin
AU  - Schmitt, Jochen
AU  - Schuler, Markus K
AU  - Eichler, Martin
TI  - The health-related quality of life of sarcoma patients treated with neoadjuvant versus adjuvant radiotherapy - Results of a multi-center observational study.
JO  - Radiotherapy and oncology
VL  - 189
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2023-01940
SP  - 109913
PY  - 2023
N1  - Volume 189, December 2023, 109913
AB  - The sequence of radiotherapy and resection in patients with soft tissue sarcomas is usually discussed on an individual basis. Better understanding of potential differences of health-related quality of life (QoL) between patients undergoing adjuvant (ART) versus neoadjuvant radiotherapy (NART) is therefore helpful for clinical decision making.Adult sarcoma patients from 39 hospitals completed the European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30). Differences in global QoL, physical functioning, role functioning, fatigue, pain, and insomnia between ART versus NART were investigated with multivariate regression, adjusting for age, gender, chemotherapy, grading, stage, tumor location, recurrence/distant metastasis, sarcoma type, time since last treatment, and treatment status using validated thresholds.A total of 1110 patients participated. Of them, 340 had received radiotherapy (NART: n=95, 28
KW  - Health Care Quality, Access, and Evaluation (Other)
KW  - Leiomyosarcoma (Other)
KW  - Liposarcoma (Other)
KW  - Neoadjuvant Therapy (Other)
KW  - Neoplasms, Connective and Soft Tissue (Other)
KW  - Patient Reported Outcome Measures (Other)
KW  - Quality of life (Other)
KW  - Radiotherapy (Other)
KW  - Radiotherapy, Adjuvant (Other)
KW  - Sarcoma (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:37739319
DO  - DOI:10.1016/j.radonc.2023.109913
UR  - https://inrepo02.dkfz.de/record/283154
ER  -