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@ARTICLE{Karur:283172,
      author       = {G. R. Karur and A. Aneja and J. Stojanovska and K. Hanneman
                      and R. Latchamsetty and D. Kersting$^*$ and P. S. Rajiah},
      title        = {{I}maging of {C}ardiac {F}ibrosis: {A}n {U}pdate, {F}rom
                      the {AJR} {S}pecial {S}eries on {I}maging of {F}ibrosis.},
      journal      = {American journal of roentgenology},
      volume       = {222},
      number       = {6},
      issn         = {0002-9580},
      address      = {Stanford, Calif.},
      publisher    = {Highwire Press},
      reportid     = {DKFZ-2023-01951},
      pages        = {e2329870},
      year         = {2024},
      note         = {2024 Jun;222(6):e2329870},
      abstract     = {Myocardial fibrosis (MF) is defined as excessive production
                      and deposition of extracellular matrix (ECM) proteins,
                      resulting in pathologic myocardial remodeling. Three types
                      of MF have been identified: replacement fibrosis from tissue
                      necrosis, reactive fibrosis from myocardial stress, and
                      infiltrative interstitial fibrosis from progressive
                      deposition of non-degradable material such as amyloid. While
                      echocardiography, nuclear medicine, and CT play important
                      roles in the assessment of MF, MRI is pivotal in the
                      evaluation of MF, using the late gadolinium enhancement
                      (LGE) technique as a primary endpoint. The LGE technique
                      focuses on the pattern and distribution of gadolinium
                      accumulation in the myocardium and assists the diagnosis and
                      establishment of the etiology of both ischemic and
                      non-ischemic cardiomyopathy. LGE MRI aids prognostication
                      and risk stratification. In addition, LGE MRI is used to
                      guide management of patients being considered for ablation
                      for arrhythmias. Parametric mapping techniques, including T1
                      mapping and extracellular volume measurement, allow
                      detection and quantification of diffuse fibrosis, which may
                      not be detected by LGE MRI. These techniques also allow
                      monitoring of disease progression and therapy response. This
                      review provides an update on imaging of MF, including
                      prognostication and risk stratification tools,
                      electrophysiologic considerations, and disease monitoring.},
      subtyp        = {Review Article},
      cin          = {ED01},
      ddc          = {610},
      cid          = {I:(DE-He78)ED01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37753860},
      doi          = {10.2214/AJR.23.29870},
      url          = {https://inrepo02.dkfz.de/record/283172},
}