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@ARTICLE{Lang:283176,
      author       = {T. J. L. Lang and F. Damm$^*$ and L. Bullinger$^*$ and M.
                      Frick$^*$},
      title        = {{M}echanisms of {R}esistance to {S}mall {M}olecules in
                      {A}cute {M}yeloid {L}eukemia.},
      journal      = {Cancers},
      volume       = {15},
      number       = {18},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2023-01955},
      pages        = {4573},
      year         = {2023},
      abstract     = {In recent years, great progress has been made in the
                      therapy of AML by targeting cellular processes associated
                      with specific molecular features of the disease. Various
                      small molecules inhibiting FLT3, IDH1/IDH2, and BCL2 have
                      already gained approval from the respective authorities and
                      are essential parts of personalized therapeutic regimens in
                      modern therapy of AML. Unfortunately, primary and secondary
                      resistance to these inhibitors is a frequent problem. Here,
                      we comprehensively review the current state of knowledge
                      regarding molecular processes involved in primary and
                      secondary resistance to these agents, covering both genetic
                      and nongenetic mechanisms. In addition, we introduce
                      concepts and strategies for how these resistance mechanisms
                      might be overcome.},
      subtyp        = {Review Article},
      keywords     = {AML (Other) / BCL2 (Other) / FLT3 (Other) / IDH1/IDH2
                      (Other) / gene mutations (Other) / precision medicine
                      (Other) / resistance (Other) / small molecule (Other) /
                      targeted therapy (Other) / venetoclax (Other)},
      cin          = {BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)BE01-20160331},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:37760544},
      doi          = {10.3390/cancers15184573},
      url          = {https://inrepo02.dkfz.de/record/283176},
}