%0 Journal Article
%A Gambichler, Thilo
%A Schuleit, Nadine
%A Susok, Laura
%A Becker, Jürgen
%A Scheel, Christina H
%A Torres-Reyes, Christian
%A Overheu, Oliver
%A Reinacher-Schick, Anke
%A Schmidt, Wolfgang
%T Prognostic Performance of Inflammatory Biomarkers Based on Complete Blood Counts in COVID-19 Patients.
%J Viruses
%V 15
%N 9
%@ 1999-4915
%C Basel
%I MDPI
%M DKFZ-2023-01957
%P 1920
%D 2023
%X With the end of the pandemic, COVID-19 has entered an endemic phase with expected seasonal spikes. Consequently, the implementation of easily accessible prognostic biomarkers for patients with COVID-19 remains an important area of research. In this monocentric study at a German tertiary care hospital, we determined the prognostic performance of different clinical and blood-based parameters in 412 COVID-19 patients. We evaluated the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and absolute eosinopenia (AEP, 0/µL) of COVID-19 patients (n = 412). The Siddiqui and Mehra staging proposal, the WHO clinical progression scale, and COVID-19-associated death were used as COVID-19 outcome measures. With respect to Siddiqi and Mehra staging, patient age of older than 75 years, high C-reactive protein (CRP), absolute eosinopenia (AEP), cardiovascular comorbidities, and high ferritin were significant independent predictors for severe COVID-19. When outcome was determined according to the WHO clinical progression scale, patient age of older than 75 years, high CRP, high LDH, AEP, high neutrophil-to-lymphocyte ratio (NLR), and the presence of pulmonal comorbidities were significant independent predictors for severe COVID-19. Finally, COVID-19-associated death was predicted independently by patient age of older than 75 years, high LDH, high NLR, and AEP. Eosinopenia (< 40/µL) was observed in 74.5
%K C-reactive protein (Other)
%K SARS-CoV-2 (Other)
%K comorbidities (Other)
%K eosinopenia (Other)
%K eosinophils (Other)
%K ferritin (Other)
%K lactate dehydrogenase (Other)
%K systemic immune-inflammation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:37766326
%R 10.3390/v15091920
%U https://inrepo02.dkfz.de/record/283178